Quote:
Originally Posted by AndreLaplume  I thought the study said the mice were cured by, in effect, destoying those nuero cells.... |
I've gone over this another time. I think what they're saying is that removing those nerve cells
prevents diabetes, but does not cure it. I've edited the following information to make is more readable (I hope):
'“We...found that specific sensory neurons are critical for islet immune attack... These nerves secrete
insufficient neuropeptides which sustain normal islet function, creating a vicious circle of progressive islet stress.”
Using diabetes-prone NOD mice...the research group learned how to
treat the abnormality by supplying neuropeptides and even reversed established diabetes.
“The major discovery was that removal of sensory neurons
expressing the receptor TRPV1 neurons in NOD mice
prevented islet cell inflammation and diabetes in most animals...Disease protection occurred despite the fact that autoimmunity continues in the animals. This helped us to focus our studies on finding the new control circuit in the islets.”
Strikingly,
injection of the neuropeptide substance P cleared islet inflammation in NOD mice within a day and independently normalized the elevated insulin resistance normally associated with the disease. The two effects synergized to reverse diabetes without severely toxic immunosuppression.'
From what I read it appears on the one hand they are talking about the removal of sensory nerves expressing the receptor TRPV1 neurons preventing inflammation and diabetes, while on the other hand they are talking about reversing (curing) established diabetes by adding neuropeptides. (I'm wondering, too, if the neuropeptides to which they refer are actually the capsaicin. Hmm.) Anyone else have any thoughts on this?
I guess I'll have to go do some research on TRPV1 receptor neurons and neuropeptides . . .
Jak
