excerpt:
"I am wondering whether the HCTZ could have caused the diabetes. I have read a few studies from 1989-90 which associate thiazide drugs with the development of diabetes. See, for example, N.Eng.J.Med. 1989; 321:868-873. The studies concluded that thiazide drugs cause insulin resistance -- and may cause or significantly increase the risk for developing Type 2 diabetes. Subsequent articles criticized the studies' conclusions because the studies involved mostly overweight, older individuals who were taking HCTZ for high blood pressure (not for kidney stones). Thus, the critics concluded that most of the subjects who developed diabetes or glucose intolerance during HCTZ therapy would have developed it anyway and that the thiazides may have merely unmasked latent diabetes that was already in existence. However, despite these criticisms, the recently published Johns Hopkin Guide to Diabetes discusses thiazides as though they may cause diabetes".
see:
children with DIABETES - Ask the Diabetes Team
