| If you are able to produce a lot of insulin it is possible for glyburide to make you hypo. How much insulin your pancreas will produce on this sulfonylurea drug is not entirely predictable. So, yes, you need to be prepared for possible hypos.
For the year that I was on glipizide, I carried candy and my meter everywhere. I didn't dare leave without it, because I did have hypos. After a while, though, I switched to glucose tablets since I could more conservatively match my intake to the amount of sugar needed.
But use that darned meter to tell you when and how much to treat! And test again after treating to make sure you are going in the right direction.
My very last hypo before I got off glipizide, I went down to 43 and had to keep taking more glucose tabs over the next 6 hours (!) because I kept dropping down to the 50's. My pancreas was really pumping out the insulin. I was trying not to overtreat, but had to keep eating glucose tabs because there was so much insulin. (I was only on 2.5 mg extended release glip' daily.)
For me, I hate sulfonylureas! My life, my health, my diabetes is much better without them. I have insulin resistance, but evidently no problem producing lots of insulin. I've chosen to go very low carb instead. Now, I don't even always take my meter with me, much less glucose tabs. I'm untethered and never need to eat like NOW as I did on glipizide. In the future, I would rather inject a measured amount of insulin than produce an unpredictable amount of it due to sulfonylurea pills. But I guess a lot of people are successful with it for some years before going to injected insulin.  | 
