| Hi folks,
I missed this thread, but I would like to weigh in as it is really important.
Doctors have been going on for years about how Type 2 is caused by insulin resistance. But that isn't what they are finding now that they are looking at the genes associated with Type 2. Just last week an article about MODY and genetic diabetes that went out on the AP news wire featured a quote from a doctor at MIT saying that surprisingly, all the Type 2 genes they've found so far affect NOT insulin sensitivity but insulin secretion.
When your blood sugar goes way up, you become insulin resistant. High blood sugars do that. And you gain weight in the early stages of blood sugar dysregulation which will increase the insulin resistance. But your blood sugar doesn't go out of control in the first place unless it started out marginal and that may not happen unless you have some kind of initial secretory defect.
So it is much more complex than the oversimplified picture doctors learned in school years ago.
I am very insulin sensitive. Two units of Lantus are too much for me. I covered a big chunk of pastry today with 3 units of Novolog and was at 98 90 minutes later.
But even so, if I stop taking metformin my insulin need goes up 33% even if that means only 1 more unit, proportionally, it's a lot. And even more important, without metformin even if my blood sugars are rock solid normal, I'll gain weight like crazy and that weight will be on my abdomen. So in a weird way, I am IR and insulin sensitive at the same time.
I think it will turn out that there are a lot more insulin sensitive type 2s out there than doctors ever realized, now that doctors are no longer waiting until a person is about to go blind and lose their toes to give them insulin.
Had I not been put on insulin, I would have gone to my grave believing I was, as I was told, "A typical type 2."  | 
