Quote:
Originally Posted by lottadata  .... When your blood sugar goes way up, you become insulin resistant. High blood sugars do that. And you gain weight in the early stages of blood sugar dysregulation which will increase the insulin resistance. But your blood sugar doesn't go out of control in the first place unless it started out marginal and that may not happen unless you have some kind of initial secretory defect..... |
I agree that high blood sugar increases insulin resistance - I have experienced it many times. But T2 insulin resistance is quite different. Large amounts of insulin are needed to keep blood glucose down. This insulin resistance has nothing to do with high blood sugar. There are high insulin levels when blood glucose is near normal. It is not uncommon for a T2 with only slightly elevated fasting blood glucose to have a fasting insuli level of 90+. Normal is about 10. That means the beta cells are producing 9 times as much insulin as would normally be required to maintain normal blood glucose. The beta cells are producing plenty of insulin. It just isn't being used as well as it should be.
While the causes of it are not well understood, insulin resistance is a very real phenomenon. The jury is still out on just what causes the decline in beta cell function. When blood sugar starts rising in a T2, up to 40% of beta cells have already been lost. Traditionally, this was thought to be caused by "beta cell burnout" - the overuse of beta cells to counter insulin resistance. But it seems that this may not be the case.
Having said all that, it still doesn't make sense fo a T2 to be insuli sensitive. If after being put on insulin a supposedly T2 diabetic is found to be insulin sensitive, they were probably never T2 in the first place.
Thats my take on it, anyway
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