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  #9 (permalink)  
Old 03-28-2008, 07:54 PM
BlueSky's Avatar
BlueSky BlueSky is offline
Senior Member
I am a: Type 1
 
Join Date: Sep 2006
Location: Auckland, New Zealand
Posts: 1,904
Quote:
Originally Posted by Ronin View Post
.... are there any anti-insulin arguments out there? ....
Insulin is a natural hormone, so it doesn't do any harm if it is used properly. But a common reservation of injecting insulin for T2s is that it adds fuel to the insulin resistance fire. This is a valid concern. For whatever reason, the cells are shutting glucose out by down-regulating the number of insulin receptors. Injecting insulin aggravates this process. And increasing amounts of injected insulin may be required to keep blood glucose down as insulin resistance escalates. A more sensible strategy, is to improve insulin sensitivity.

In your case, there seems to be no evidence of insulin resistance. And, and bearing in mind your normal weight and active lifestyle, there is not much room for improving insulin sensitivity. Blood glucose is near-normal and c-peptide is low, at the same time. If there was insulin resistance, one would expect to see high blood glucose and/or high c-peptide. As you say, your problem appears to be reduced beta cell output. Injecting supplemental insulin would just be closing the gap between your body's needs and what your beta cells are producing. And it seems most unlikely that doing this would cause insulin resistance.

Having said all that, the causes of insulin resistance are still a bit of a mystery. So who knows might happen ...
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Type1 since 1977
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