[lottadata]

Dave,

I know what you mean about wanting the diagnosis but fearing it won't come through so you'll be left scratching your head again.

But it is important to remember that if you have the personal and/or family history suggestive of that kind of problem, the gene tests are not definitive. On the Joslin site where they discuss MODY they say they believe there are many more MODY genes that are not yet identified. I spoke to someone who was recruiting for their MODY gene project there who told me the same thing.

At my endo appointment last week the doctor suggested that I try Prandin along with the other insulins, so I figured, why not. I started with 1/4 of a .5 mg tablet which was better than nothing but not quite strong enough. So I boosted it to 1/2 a tablet today and it did very well at lunch where I ate a meal that can be a problem with insulin as it blends fast and slow carbs. I peaked at 123 at 1 hour and ended up at 93 at 3 hours. I would be VERY happy if that turns out to be reproducible. That was with about 45 grams of carb.

If I can get that kind of result reliably, I might be able to replace the insulin. It was so much more mild than the Amaryl which was terrifyingly overpowering even at a tiny dose.

The biggest concern I have about Prandin is hunger. I've heard reports it makes people hungry and can cause weight gain.
And the other problem is that I'm used to titrating insulin very closely to what I eat, and don't like the idea of eating to the drug. I am old and small so it takes a tiny amount of calories to keep me going. I will gain weight eating an extra couple hundred calories a day.