| Dodo, it's odd that you would go from NPH once a day to Lantus once a day. If you truely need Lantus, then you should be giving your NPH twice a day. Like I mentioned before, NPH lasts 12-16 hours and someone else mentioned the huge peak. It definitely does not last 24 hours and therefore to me it seems you are not getting all the insulin you need. I'd definitely bring up a new course of action at your next doctor appointment.
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