| When I used to use "milky" insulins such as NPH, I was instructed to roll the bottle between my hands like a piece of clay to mix the crystals and the clear insulin. My answer would be no, I don't think motion hurts it.
I have had bottles go bad. Three to be exact in a LOT of years. All were either Humalog or Novalog. Two were from exposure to heat (one in my purse during lunch--I didn't notice it was in the sun) and one came that way from the store--a large volume drug store.
So it could be heat or it could be Jumbies (as they say in the Caribbean.)
Just my opinion, Mich | 
