I've also used both the One Touch Ultra and Freestyle Flash, and have to agree with the others. I used to solely use the Ultra (while insurance covered strips), but later switched to the Flash (to see if I'd like it and to prepare for the Cozmonitor's release). I like how the Flash doesn't start countdown until enough blood has been applied. JasonJayhawk gave a good comparison of the two. The size of the numbers and display (on the Flash) could pose a concern for your grandmother. In that case, it may be best for her to go with the UltraSmart, but as Shy said, YMMV (Your Mileage May Vary).
The meter that lg described (the Accu-Check VoiceMate) is a good one, but the price is extremely steep (the cheapest price I've found was $399.00! <or about that>). Hope this helps, and keep us posted on which one she goes with, and how she likes it.

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ALL my love, Carwy & Best wishes for a healthy new beginning!
Saying prayers for him & all our friends, every day.
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"Someone must speak for them. I do not see a delegation for the four footed. I see no seat for eagles. We forget and we consider ourselves superior, but we are after all a mere part of the Creation."
--Oren Lyons, ONONDAGA
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Pumps & Meters Used:
MM506,7,8,11 & 12, Cozmo, Animas 1200 & 1250
Many
A1C: 6.4
Type I 26yrs, pumping 12