11-06-2008, 01:24 PM
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 | Senior Member
I am a: Type 2 | | Join Date: Oct 2007 Location: Vermont
Posts: 2,293
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| Motor protein Myo1c is key to insulin resistance
Not a cure. but a "significant clue" to T2 Completely Novel Action Of Insulin Unveiled
ScienceDaily (Nov. 6, 2008) — A Ph.D. student at Sydney's Garvan Institute of Medical Research has uncovered an important piece in the puzzle of how insulin works, a problem that has plagued researchers for more than 50 years. The research brings scientists one step closer to explaining exactly how insulin prompts fat and muscle cells to absorb glucose.
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"I have discovered that insulin activates a specific kind of motor protein known as Myo1c, which in turn performs a critical role in glucose uptake."
Insulin controls glucose uptake into our fat cells by moving glucose transporter proteins from inside the cell to the surface membrane so that they can pump glucose into the cell. Myo1c aids in this process by helping the transporters slide into the surface membrane.
In healthy people, around 80% of the glucose transporters migrate to the cell membrane after a meal, allowing plenty of glucose into the cell. In people with Type 2 diabetes, however, that figure drops to around 10%...
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