Welcome to the Forums, DealCorn
I've never personally used Lantus, but I have seen studies about it which suggest that it is no better or worse than NPH with regards to asymptomatic hypoglycemia. I have a document (paper unfortunately, not online) that says that if a patient is given a starting dose of 20-25% less Lantus than previously taken NPH (twice daily) the chance of nocturnal hypoglycemia is reduced. Most episodes (I read a study showing approx. 60% of participants) of nocturnal hypoglycemia
are asymptomatic (BG levels <2.6mmol/47mg), very common and last >4 hours. An A1c held consistently <6.0% can also cause hypoglycemic awareness by inhibiting the autonomic responses of epinephrine and norepinephrine.
Based on the clinical knowledge that
for most people, Lantus is peakless and disregarding any possible chemical interaction, I would agree with Mark and suggest that you test your overnight basal dosage. It is definitely a prudent place to start to determine whether it's the dosage or a chemical reaction of the Lantus. Many people here have found better success in splitting their Lantus dose, and based on the results that you may get from testing during the night, this may be an option that will help you.
Let us know how it all turns out for you.
Shy
