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  #12 (permalink)  
Old 01-11-2005, 11:14 AM
jacobsam622's Avatar
jacobsam622 jacobsam622 is offline
Senior Member
I am a: Type 2
 
Join Date: Aug 2004
Location: Mind -Langhorne PA Heart - The Shenandoah Valley
Posts: 635
this could be a side effect of taking Actos

MONITOR:
Grapefruit juice may increase the plasma concentrations of some orally administered drugs that are substrates of the CYP450 3A4 isoenzyme. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruits. The extent and clinical significance are unknown. Moreover, pharmacokinetic alterations associated with interactions involving grapefruit juice are often subject to a high degree of interpatient variability.

MANAGEMENT:
Patients who regularly consume grapefruits and grapefruit juice should be monitored for adverse effects and altered plasma concentrations of drugs that are metabolized by CYP450 3A4. Grapefruits and grapefruit juice should be avoided if an interaction is suspected. Orange juice is not expected to interact with these drugs.
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