| Humalog - 1996
Novolog/NovoRapid - 2001
Lantus - 2001
Apidra - 2005
Levemir - 2006 (late 2005 for some countries outside the USA)
MDI has really been around as long as people were able to utilize the concept - the major disadvantage for most was not the insulins available, but the lack of accurate home testing, which wasn't really available until the mid-80's. Many people also found MDI to be too much work with R and N, and preferred the old 2-shot regimen which was standard for a long time (which I see as good enough to keep someone alive, but about the *worst* option available). More shots = more work, and a lot of people back then really didn't see the difference it would make to their long-term health. | 
