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Originally Posted by Subby  Here's a diagram that should help to illustrate just how (not) flat Lantus is over the 24 hours. Lantus of course being the Glargine. This is the reduced version, a larger version of this picture does go into details of the study and how they came about this data, can be found. 
If you split at 12 hours apart, you get a more even effect over the 24 hours. I don't have a diagram for that, if you can't visualise it, try drawing it - repeat the curve at the 12 hours mark, overlapping the first curve, and notice the resulting more even top line over the time period.
As well as this curve of action found to be inherent in the insulin, people can metabolise insulin at a different rate, and some find Lantus runs out before the 24 hour mark. |
Ah great! Super helpful picture.. I AM the visual type for sure.. Lantus is also the most even burn it seems. So with me taking my full dose at 9:30am -I am virtually getting no help from Lantus overnight and by my wake up time... Interesting.. But a 9:30 am, 9:30PM of 12units each... would give me a smoother burn but at NO point would it be MORE then 24 units -- right? That's what I'm trying to avoid.. And I also don't want to go low overnight -- So maybe it would be better to back down to 10 units + 10 units and see what that does and then work back up.. Because at my current dose from an 8:30am-9:30am injection -- when I exercise mid afternoon I've gone low twice now -- because that's the peak.. Interesting..
I guess for a T2 you'd have to figure in your most carb sensitive times of the day too. For me that's am.. So maybe even a 8 units am and 12 units PM split would account for a more carb sensitive am.. Am I think correctly about that?
Thanks again, Subby!
