What would happen if I mixed Lantus with Novolog?

[racinghoss]

Everyone's responses here are odd to me. I inject Lantus and Novolog, as does my daughter. When asked about mixing the insulin to reduce the number of injections and save syringes, my Endo Doc told me that mixing would be OK. She did stipulate that we only use the needle one time, and draw up the Novolog first, then the Lantus. When I draw up the Novolog and then the Lantus, the fluid in the syringe gets cloudy. However, the insulin in the vials never gets cloudy and apparently still works like it is supposed to.

[Subby]

Hey, whatever works for you, but consider these things.

1. Not recommended by manufacturer. Hardly "odd" to follow these instructions.

2. Clinical trials indicate it does indeed affect the action of the insulin. Such as:
The early pharmacodynamic and pharmacokinetic effects of mixing lispro with glargine insulin: results of glucose clamp studies in youth with type 1 diabetes.

Conclusion: These data demonstrate that mixing lispro with glargine markedly flattens the early pharmacodynamic peak of lispro and causes a shift to the right in the GIR curve changes that might lead to difficulties in controlling meal-related glucose excursions.

This is quite a recent study. I wonder if your endo is aware of it.

[Cblake]

I agree with this, freebasing your insulin is bad. Novalog is not suppost to be mixed with anything. per them.

[rashonda]

I would suggest you switch to the Lantus Solostar pen and eliminate this problem. I don't, but others that use the Lantus Solostar pen, or other pens, reuse their pen needles. In this way any cross contamination is virtually impossible. The possibility also exists that even though you might try using different color syringes...that system can also be compromised. You retinas cannot see the difference in colors in low light.

Oops, forgot to answer your question: If you mix Lantus and Novolog together...your body will swell up twice its size and explode. If you're going to do this I suggest you do it in the bathroom. Less forensic clean up.

Hi, I use lantus solostar pen, and novalog pen, and it is wayyyyyyy better! I have a little pen needle that i screw on the end i dial up and im ready to go the needle barely hurts and it is way mor convenient and discreet!