[Injecto]

I would like to know what people would label the diabetic situations below. There are some small but definite differences between all of them.
What type would you label those below as they are NOW?


1 - You produce little or no insulin?

2 - You are resistent to insuling?

3 - You produce little or no insulin AND are resitant to insulin?

4 - You used to be ONLY resistent to insulin and NOW your pancreas stopped producing insulin (or makes very little)?

5 - You used just produce little or no insulin but now you are ALSO resistent to insulin?

6 - You were dropped kicked by a Ninja in the pancreas?

[Funnygrl]

Originally Posted by Injecto

I would like to know what people would label the diabetic situations below. There are some small but definite differences between all of them.
What type would you label those below as they are NOW?

All of them are- "It depends."


1 - You produce little or no insulin?- Type 1 if it occurred quickly, and there's evidence an immune attack caused it. Type 1.5 if it occurred not-so-quickly and there's evidence of an immune attack. Type 2 if it took more than 5 years to happen.

2 - You are resistant to insulin?- If that is the sole reason you have high bs, then type 2. However, type 1s can be resistant too, but it's certainly not the only reason their bs is high.

3 - You produce little or no insulin AND are resistant to insulin?- If the person was originally type 1 and then became resistant, double diabetes. If the person was originally type 2 and then rapidly became insulin dependent and there's evidence of it being from an immune attack, also double diabetes. If the person was type 2 and slowly experienced increasing insulin dependency, that's the regular progression of plain old type 2.

4 - You used to be ONLY resistant to insulin and NOW your pancreas stopped producing insulin (or makes very little)?- See #3

5 - You used just produce little or no insulin but now you are ALSO resistent to insulin?- See #3

6 - You were dropped kicked by a Ninja in the pancreas?- Diabetes NOS

[DeusXM]

It's very simple. If you don't produce any insulin because your immune system keeps destroying your beta cells, you have T1, irrespective of your insulin resistence. Any other form of diabetes is either T1.5, gestational or T2, regardless of whether or not you produce insulin. T1 denotes diabetes caused by an autoimmune trigger; T2 denotes diabetes caused by a non-autoimmune trigger.

[June91]

Originally Posted by DeusXM

It's very simple. If you don't produce any insulin because your immune system keeps destroying your beta cells, you have T1

But is it beta cells that the immune system keeps destroying? I asked this in another thread (about C peptide):

Originally Posted by June91

I've been wondering about C-peptide in Type 1 in general... It does definitely prove that no natural insulin is present. But that does not necessarily mean that:

a) The beta cells are dead - they could be malfunctioning or unresponsive, much like a broken thermostat;

b) That beta cells are even malfunctioning - it could be that the insulin they produce is immediately recognized as a foreign body (for example due to a fault in the immune system) and destroyed.

Hopefully someone with a better knowledge of chemistry can clarify this, but I think there's still no method to prove any of the above for certain.

Go ahead, make my day

[Funnygrl]

Amylin is also produced by the beta cells of the pancreas, and is also absent in type 1 diabetes, therefore suggesting that the problem is at the beta cell level.

Further, autopsy views of the islets of langerhans show a clear difference in physical appearance in those with type 1 diabetes.

Further still, if the problem was that the insulin was destroyed, islet and pancreas transplants wouldn't work at all.

[June91]

Makes sense, thanks.

[Stuboy]

1 - You produce little or no insulin? Type 1

2 - You are resistent to insuling? Type 2

3 - You produce little or no insulin AND are resitant to insulin? Type 1 (out of luck?) MODY OR LADA? not sure.

4 - You used to be ONLY resistent to insulin and NOW your pancreas stopped producing insulin (or makes very little)? Type 1.5

5 - You used just produce little or no insulin but now you are ALSO resistent to insulin? Type 1 MODY OR LADA?

6 - You were dropped kicked by a Ninja in the pancreas? Unlucky

Ill admin I know NOTHING about LADA and MODY.

[HelenM]

Ill admin I know NOTHING about LADA

LADA :Latent Autoimmune Diabetes of Adults sometimes called 1.5 (but different authors seem to use 1.5 for different conditions)

'LADA is a Type 1 diabetes. In children the speed at which the body destroys these cells is very fast. Therefore, in children there is a very quick development from symptoms of diabetes (tiredness, thirst, urination) to absolute insulin dependency (collapse and diabetic coma). However, in adults the speed at which the body destroys insulin making cells can be slower. It can take 1-6 years to become dependent on insulin. This means it can be difficult to identify that a person has this type of diabetes'
(from the Swansea University research into LADA website)

So 3,4 and 5 are not LADA.

I agree with Funnygirls answers

[lilituc]

Originally Posted by Stuboy

5 - You used just produce little or no insulin but now you are ALSO resistent to insulin? Type 1 MODY OR LADA?

Neither. MODY is a defect in insulin secretion, and LADA is just like regular Type 1, but slower onset and after age 25. I guess insulin resistance is theoretically possible (like with double diabetes), but it's not the cause.

I agree with Funnygrl also.

[Harold]

Originally Posted by DeusXM

It's very simple. If you don't produce any insulin because your immune system keeps destroying your beta cells, you have T1, irrespective of your insulin resistence. Any other form of diabetes is either T1.5, gestational or T2, regardless of whether or not you produce insulin. T1 denotes diabetes caused by an autoimmune trigger; T2 denotes diabetes caused by a non-autoimmune trigger.

Let us not forget that there is that theory that type 2 is caused in part by inflammation which is an autoimmune response. Oh! the water keeps getting murkier!

Never the less type 1 is caused by the active destruction of beta cells by T-1 cells. Which is not the case in type 2 where beta cell loss is attributed to beta cell wear out.

[Funnygrl]

Correct me if I'm wrong, but all inflammation isn't autoimmune...