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05-27-2007, 08:33 PM
| | Junior Member | | Join Date: May 2007
Posts: 7
| | | Big Resistance Problem.... Need Help ASAP!
I went to the doc the other day and my A1C was 6.8. I am on Lanuts and Apidra. He wanted to add Metformin to my regiment. I had DKA last year as a result of taken Metformain all by itself. He didn't see any problem with me taking it again.
I stratred taking it the other day and instantly my insulin resistance skyrocketed. No mounter how many hundreds of units of Apidra (300-600 units) I injected it would not budge.
I went to the hospital and the doctor was like "your blood sugar is 118 what do you want form us"? I said it took me like 600 units for me to get it from 280 to 140. He had no answers for me and told me to see my endocrinologist. Well I can't go see him because it's a 3 day weekend.
What the **** is going on? My resistance went nuts. It takes hundgreds of units to drop it 30 -60 units.
Has anyone heard of this before? What should I do? I have a BS of 300 right now and injected 300 units to drop it.
Any ideas?
Thanks! |
05-27-2007, 08:48 PM
|  | Senior Member
I am a: Type 2 | | Join Date: Dec 2006 Location: Tennessee
Posts: 543
| | | That's new to me, pilot. I take metformin with good results. Perhaps other users of metformin know more along this line.
Are you T-1 or T-2?
__________________
I was born with nothing and I've still got most of it. |
05-27-2007, 08:58 PM
|  | Super Moderator
I am a: Type 2 | | Join Date: Feb 2002 Location: Do Dah, OZ, aka Kansas
Posts: 4,451
| | | Jetpilot with uncontrolled diabetes.....BIZAAR!
Metformin does not cause DKA or increase resistance.
What and how much are you eating to cause you to go to 300?
Are you type 2 or type 1 with insulin resistance? |
05-27-2007, 09:56 PM
| | Junior Member | | Join Date: May 2007
Posts: 7
| | | The day I started Metformain my control went to sh*t and my insulin basiclly stopped working. I am type 2.
Metformin in some cases does contribute to DKA.
I am @ 300 because my insulin is not working!!!!
I injected 300 units and 1 hour later it rose 30 points to 330. So now I am at 330 and just injected another 200 units.
My pancreatic output was 1.8 last weak. So that's within normal parameters.
Doctors SUCK! I can't believe they sent me home!!!
JET |
05-27-2007, 10:11 PM
|  | Super Moderator
I am a: Type 1 | | Join Date: Aug 2003 Location: Northern California
Posts: 6,226
| | | Your A1c was pretty good on Lantus and Apidra. Why are you changing that regime?
I am not sure what you expected the doctor in the ER to do Jet. Have you considered stopping the Metformin and go back on your Lantus/Apidra routine until Tuesday? |
05-28-2007, 12:37 AM
| | Senior Member
I am a: Type 1 | | Join Date: Dec 2005 Location: UK
Posts: 791
| | | Are you sure your insulin hasn't gone off?
__________________
Sue
Pumping using bovine insulin. (Pump kindly donated by Solox)
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05-28-2007, 03:44 AM
| | Junior Member | | Join Date: May 2007
Posts: 7
| | | I did stop my Metformin 2 days ago and the resistance is still there.
I wanted the doctor in the ER to at least do some blood/urine lab work.
Well I just got back from the emergency room again and they had no answers for me. They did say..." You took how much insulin and your still walking?" Sooooo no one can figure this out. Thye observed me for 3 hours to make sure I didn't crash which I didn't and they said you should not be alive and I replied... yeah I know that's the problem.
As far as the insulin being bad.... I used Apidra from 3 different sources. I tired 5 different bottles from 2 different pharmacies, and some samples from my Endocrinologist he gave me when I visit.
This has something to d owith the Metformin because this is the only change I made to my regiment. And the same day I started taking my Metformin I lost control.
JET |
05-28-2007, 04:17 AM
|  | Senior Member
I am a: Type 1.5 | | Join Date: Feb 2005 Location: Grove City Ohio
Posts: 2,093
| | | Have you by chance tried Humalog or Novolog in place of Apidra? I don't know the answer to this, but Apidra was the worst of the 3 when it came to bringing my numbers down. I used more Apidra then the other 2. Just a thought.
__________________ Jim  Diagnosed April 1990 Pumping with the Clear 722 along with the CGMS
Last A1C 7.1 ( February 2008 ) Diabetes & Endocrinology Center Of Ohio Website Proud Fan Of NASCAR Nextel Cup Driver Jimmie Johnson, Lowes #48 the 2006 AND 2007 Nextel Cup Champion. The opinions expressed are mine alone and do not necessarily represent
those of my wife who runs our house and makes more important decisions
than I do |
05-28-2007, 04:36 AM
| | Senior Member
I am a: Type 1 | | Join Date: Dec 2005 Location: UK
Posts: 791
| | | OK so you have changed the Rapid have you changed the Lantus?
If both ok do you take Lantus once or twice a day?
If once/day then talk to your endo about splitting the dosage.
Many find once/day does not give them coverage.
__________________
Sue
Pumping using bovine insulin. (Pump kindly donated by Solox)
|
05-28-2007, 08:55 AM
|  | Senior Member
I am a: Type 1.5 | | Join Date: Feb 2006 Location: Orlando, FL
Posts: 7,832
| | | Are you sure you are type 2 and have you ever considered a pump?
__________________
You may call me Locutus  |
05-28-2007, 11:14 AM
|  | Senior Member
I am a: Type 2 | | Join Date: May 2007 Location: illinois
Posts: 3,316
| | | hi jetpilot!metformin is supposed to help with the insulin resistance...and it doesn't cause dka.mega high sugars causes dka...how many carbs do you eat/day?maybe cut the carbs down a bit?take care,trish |
05-28-2007, 02:31 PM
|  | Senior Member
I am a: Type 1 | | Join Date: Apr 2007 Location: Bucks County, PA, USA
Posts: 798
| | | Are you on a steroid of any kind right now?
__________________ 
Unless otherwise stated, the opinions expressed here are my own and are in no way intended to be considered as anything other than my opinion. That's my story and I'm stickin' to it.
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05-28-2007, 03:22 PM
|  | Senior Member
I am a: Type 1 | | Join Date: Dec 2006 Location: Hastings Melbourne Australia
Posts: 2,643
| |  Change Insulins...
Quote:
Originally Posted by SueM  Are you sure your insulin hasn't gone off? | Yeah, I'm begining to think that maybe be the case or change the insulin types. 
__________________ We inject to stay alive!!! So that i can enjoy what you enjoy!!!  A1C for July '08 5.9 MMOL/L
Peter... Insulins Novorapid and Levemir. 
So I am well armed to enjoy food of any kind!!!  |
05-28-2007, 03:35 PM
|  | Senior Member
I am a: Type 1 | | Join Date: Jun 2006 Location: Rothesay, New Brunswick Canada, eh
Posts: 6,453
| | | Wow. Resistance of that magnitude is not unheard of, but it doesn't just happen like that.
How much were you normally taking a day? Metformin lowers resistance, but if you think the metformin did this somehow, get someone to call your endo on the golf course. Cripes, you don't want to be taking that much and suddenly have normal resistance again.
__________________ Michael Pollan on CBC
In Defense of Food with Michael Pollan T1 1975, MM 722 pump
A1C 7/08 5.9%
HDL - 1.55 (59.9)
LDL - 1.76 (68.1)
Triglicerides - 0.44 (40.0)
Called John, plus many other things
1 - - - - - - - - - - - - - - - - - - - - - - - - - - 3 - - - - - - - - - - - - - - - - - - - - - - - - - - 5 > > > > > > >  > > > > > > > > > > > > > > > > > > > > > > > > > > >
John's Troll Meter - current level: Iffy |
05-29-2007, 11:41 PM
| | Junior Member | | Join Date: May 2007
Posts: 7
| | | Well guys.... thanks for the help. I did go to the emergency room again as I was scared and confused. They pumped a liter of saline in me and monitored my blood sugar. Upon arrival my BS was 375. After the liter and the time lapse the sugar came down to 160. The doc sent me home with no answers.
The next day I had been off the Metformin for 24 hours and my resistance/absorbtion rate started going back to normal. Today... the 3rd day it is now normal again.
No one has any answers for me as far as what happened with the Metformin and why it changed the absorbtion rate /resistance. But I won't be taking it again any time soon.
Metformin can fascilitate the onset of DKA. Go to the website and read the medical information included with the drug.
As I stated before I am type II and my pancrease has normal output.
Thanks for the help!
JET |
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