[Alice]

I do believe the cause is very different for Type 1 and Type 2. They are really two very different diseases with similar symptoms. It is my personal opinion that Type 1 is an auto immune disorder and Type 2 (and variations such as gestational) are metabolic disorders.

[Janlaton]

What is the connection betweeh "Catcher" and the rest of your post. I remember reading in way back when not sure if I want to again.

Prevacid may have speed up the diabetic process but 2 to 1 you would have been diagnosed down the line somewhere anyway. I know many things out there affect the pancreas and meds can be among them. I would not rule anything out. But I really think genetics are the biggest. In my family we say who is not diabetic not the other way round.

Janlaton
type 2 40 years.

[Petruchio]

Originally Posted by jacobsam622

If you look at the drug fact sheet for Prevacid It lists diabetes as a rare side effect.

Info based on the drug approval testing I would take with a pound of salt. Any (and I mean ANY) little thing that comes up must be listed as a possible side effect. If you were in a study and one day ate an egg salad sandwich and that sandwich caused a chemical reaction in your digestive tract . . . For the rest of time that drug would show flatulence as a possible side effect.

[jacobsam622]

I work for a drug company I think I know a little bit about drugs and how they are marketed. The reference to "Catcher in the rye" is that several high profile killers had a copy on their person when they were captured at least thats the way the urban legends go. I never said it caused the diabetes I said it triggered it. This bull about weight causing it is a lot of malarkey I was already pre-diabetic when the weight gain began. I have said this before and I will say it again in a lot of type two weight gain is a symptom not the cause. Read Gretchen's book.

[Janlaton]

Thanks for the explanation of the book. Had never heard that high profile killers had copies on them. That was required reading way back when I was in high school!

Like I said with type 2 the predispostion was probably there and the med was like a boost to speed up the time when you were diagnosed. If you were not in the drug industry you might not have even read the warnings.

[Carwy]

Heck I do not know how or why I have what ever type it is I have. We find out the 8th of May. However type 2 runs back in my family on my mothers side as far back as you can trace it back to my great grandmother.

Oh lets not for get the service to my country.Desert shield, Desert storm, and playing with WWII ordnance in the PI.

Also check this out.
Maybe we are doing this to our selfs by not making them clean the water right we drink.
Prescription drugs found in drinking water across U.S. - CNN.com

Just my thoughts.

[Funnygrl]

I've taken Prevacid for years, but really don't believe it caused my diabetes at all. Prevacid is a proton pump inhibitor. It stops these things in your stomach from excreting H+ (protons), which than binds to Cl-, thus forming HCl, aka, hydrochloric acid. I just don't see how that could in turn cause an autoimmune attack or insulin resistance.

[HelenM]

Very few of us will ever know what caused it.
I’ve read lots of theories , several sound plausible.I'm sure we tend to grasp at what fits in with our own histories.
I had hepatitis A as a child, one (really obscure) study showed that an epedemic of Hep A in a remote African tribe resulted in some immediate cases of diabetes but also instances of it developing some years later. Well mine was many years later, but perhaps it fits.
Another study suggested frequent low grade infections by the coxsackie (hand foot and mouth) virus could result in a series of minor auto immune attacks with a gradual loss and subsequent partial regeneration of beta cells. When the net loss was too great the result was type 1. As a primary school teacher I must have encountered that virus frequently, perhaps that was the reason.
One doctor has suggested stress. Maybe he was right though I think the stress symptoms were caused by undiagnosed high BS.
Who knows?

[jacobsam622]

Originally Posted by Funnygrl

I've taken Prevacid for years, but really don't believe it caused my diabetes at all. Prevacid is a proton pump inhibitor. It stops these things in your stomach from excreting H+ (protons), which than binds to Cl-, thus forming HCl, aka, hydrochloric acid. I just don't see how that could in turn cause an autoimmune attack or insulin resistance.

Just a few things proton pump inhibitor can do to us.

* Impaired synthesis of biological proteins including enzymes and hormones. The gastric enzyme pepsin is vital to protein digestion. The hormones insulin and glucagon regulate blood sugar, thyroxin regulates the body's metabolic rate, calcitonin and parathyroid hormone regulation, bone mineralization, and antidiuretic hormone regulates fluid electrolyte balance (the vital acid/base balance of cellular mineral salts including calcium, magnesium, sodium, potassium, chloride, phosphorus, bicarbonate, sulfates, protein and organic acids)

* Food allergies and leaky gut syndrome caused by incomplete protein digestion

* Calcium deficiency accompanied by abnormal bone mineralization

* Iron deficiency with risk for anemia

* Zinc deficiency with risk for impaired immune function

* Folate deficiency with risk for large cell anemia, elevated homocysteine levels and neurological dysfunction

* Vitamin B12 deficiency with risk for pernicious anemia, large cell anemia and neurological dysfunction and asthma in children

from
FDA Approves Prescription Proton Pump Inhibitor Drug for 1-11 Year Olds

[Alice]

Remember the early Greeks...I don't think they had much of a drug connection to diabetes...or obesity...so there is a lot of natural biology occuring in spite of modern science.

[dar917]

I think mostly it is genetics for Type 1s. I am at least the 8th person in my family to have it and be on insulin. It could be caused by viruses, who knows. I had two colds within two months of each other the fall before I was diagnosed and I hated my job I was at so there was that stress and not getting enough sleep and stuff. I had chickenpox as a kid, and bronchitis (I think) and many colds and flus growing up.

For T2s, I don't doubt that obesity and all the unnatural things in our environment contribute to it. I think medications causing it is a bit far fetched, but many of these drugs have not been around long enough for us to really know all the long term effects of them.

[jacobsam622]

Originally Posted by dar917

I think mostly it is genetics for Type 1s. I am at least the 8th person in my family to have it and be on insulin. It could be caused by viruses, who knows. I had two colds within two months of each other the fall before I was diagnosed and I hated my job I was at so there was that stress and not getting enough sleep and stuff. I had chickenpox as a kid, and bronchitis (I think) and many colds and flus growing up.

For T2s, I don't doubt that obesity and all the unnatural things in our environment contribute to it. I think medications causing it is a bit far fetched, but many of these drugs have not been around long enough for us to really know all the long term effects of them.

You call this far fetch
A study done by the VA indicates other wise
Abstract
Background. Metabolic changes, including weight gain and onset of diabetes, have been associated with both systemic corticosteroid use and atypical antipsychotic drugs. The purpose of this study was to quantify and compare the risk of new-onset diabetes mellitus in a Veterans Affairs population receiving antipsychotics and corticosteroids, using persons taking proton pump inhibitors as a control group.

Methods. This study included data from subjects treated within Veterans Integrated Service Network 23 who had received an outpatient prescription in fiscal years (FY) 1999 or 2000 for a corticosteroid (CS), a proton pump inhibitor (PPI), a typical antipsychotic, or an atypical antipsychotic. Patients receiving prescriptions in more than one class were not excluded. Subjects were excluded if they had a documented diagnosis of diabetes either in the previous FY year (1998) or prior to their index prescription date.

Results. Thirteen percent of the population had a new diagnosis for diabetes during the two-year study. Cox-regression analysis using time dependent covariates determined a significantly higher risk of developing diabetes (RR = 1.21) in users of CS relative to PPIs. Demographic variables including age, race, gender, marital status, and VA financial classification as well as a marker for schizophrenia, were also included in the model. Comparison of both typical and atypical antipsychotics to PPIs found an increased but nonsignificant risk of developing diabetes (RR = 1.18 and RR = 1.19 respectively).

Conclusions. The diabetogenic risk associated with atypical antipsychotics was found to be less than that of corticosteroids when compared to controls. Periodic monitoring of blood glucose should be considered with chronic use of an ag


Additional adverse experiences occurring in less than 1% of patients or subjects who received PREVACID in domestic trials are shown below:

Body as a Whole – abdomen enlarged, allergic reaction, asthenia, back pain, candidiasis, carcinoma, chest pain (not otherwise specified), chills, edema, fever, flu syndrome, halitosis, infection (not otherwise specified), malaise, neck pain, neck rigidity, pain, pelvic pain;
Cardiovascular System -angina, arrhythmia, bradycardia, cerebrovascular accident/cerebral infarction, hypertension/hypotension, migraine, myocardial infarction, palpitations, shock (circulatory failure), syncope, tachycardia, vasodilation;
Digestive System – abnormal stools, anorexia, bezoar, cardiospasm, cholelithiasis, colitis, dry mouth, dyspepsia, dysphagia, enteritis, eructation, esophageal stenosis, esophageal ulcer, esophagitis, fecal discoloration, flatulence, gastric nodules/fundic gland polyps, gastritis, gastroenteritis, gastrointestinal anomaly, gastrointestinal disorder, gastrointestinal hemorrhage, glossitis, gum hemorrhage, hematemesis, increased appetite, increased salivation, melena, mouth ulceration, nausea and vomiting, nausea and vomiting and diarrhea, oral moniliasis, rectal disorder, rectal hemorrhage, stomatitis, tenesmus, thirst, tongue disorder, ulcerative colitis, ulcerative stomatitis;
Endocrine System - diabetes mellitus,

[Hammer]

Well, just knowing how diabetes works is enough to indicate that diabetes can be triggered by various medications or exposure to certain chemicals. Think about it, for anyone who was born without diabetes, was diabetes free for years, then one day they're suddenly diabetic. Apparently their pancreas was working fine till that day, as was their body's use of insulin. They weren't low on insulin and their body didn't reject the insulin....everything worked fine till that day, so what caused things to change?

Anything that alters your body chemistry (drugs) could cause this to happen, so it's not a stretch to think that some medication that you took or some chemical that you were exposed to, could have caused this change.

They say that your DNA has a lot to do with your susceptibility to getting diabetes, but if you didn't have it before and you suddenly have it now, then something else was added to the mix, otherwise, why would your DNA suddenly change something on it's own and cause you to develop diabetes? There had to be outside elements that caused this. It could be your weight, lack of exercise, or something that you did to yourself, but why did it start now and not a year ago when you were still overweight and didn't exercise?

The fact that they think that gastric bypass surgery is effective in "curing" type 2 diabetes is due to bypassing a section of your intestine, and what happens in this section of the intestine relates to absorption of foods and the releasing of certain elements that can interfere with your body's ability to effectively use insulin, means that anything that affects this section of the intestine can initiate the onset of diabetes. That's not to say that it will initiate the onset of diabetes, but that it can.

I don't think it's a conspiracy, but it probably is a lack of knowledge about how certain drugs affect certain processes in the body that are unrelated to what the drug was designed for that might be causing diabetes to develop in people, years after they've taken the drug. I mean, if you took Nexium for acid reflux and it stopped your acid reflux, but while it was doing that, it also chemically altered your stomach pump that was producing the excess acid, and by altering the stomach pump, your digestive process had to digest the food with less acid causing your entire digestive process to change, and this change caused your intestine to have to digest the food differently since it now had less acid to work with, then this change might be what caused the onset of diabetes. The thing is, how would you be able to connect the two things together? There would be too many processes involved to clearly see how taking Nexium brought on diabetes. This is what I mean by the lack of knowledge. Add to this the fact that it might take years before one process causes a significant change in another process, and it makes it even more difficult to tie things together.

[pokie]

I have family history of diabetes, both type 1 and 2, on both sides of my family. An odd thing did happen to me though, right around the time I can first remember having symptoms... I got the mumps when I was 30. Apparently my Mom didn't get me vaccinated, or the vaccine didn't take. So, 4 years later after my daughter was born, they noted that I had no antibodies for MMR and vaccinated me again. Is there any connection? Who knows.

[dar917]

OK, now you got me thinking. I wasn't on any medications when my symptoms started. The only thing I had ever really taken before was the pill and some antibiotics for my skin, but I had stopped taking them a couple years before when my insurance ran out. I wasn't on the antibiotics that long though.

When I was in school I did a lot of walking, to class, to work, etc. then after I moved here I didn't walk much any more.

???

I'm just glad I was out of school for a while before it happened.