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05-27-2008, 08:19 AM
|  | Senior Member
I am a: Type 1 | | Join Date: Dec 2006 Location: Ontario, Canada
Posts: 1,406
| | Possible eventual cure? Pixie Dust. Alright, I'm not one for hope that's for sure, but for once I actually got a bit excited at the prospect of this article. Funny thing is I didn't even think about the diabetic implications until I read the last 3 or 4 sentences. Salamander-inspired therapy may aid injured vets - CNN.com
"Last week in an operating room in Texas, a wounded American soldier underwent a history-making procedure that could help him regrow the finger that was lost to a bomb attack in Baghdad last year.
Army Sgt. Shiloh Harris' doctors applied specially formulated powder to what's left of the finger in an effort to do for wounded soldiers what salamanders can do naturally: replace missing body parts.
If it sounds like science fiction, the lead surgeon agreed.
"It is. But science fiction eventually becomes true, doesn't it?" said Dr. Steven Wolf of Brooke Army Medical Center.
Harris' surgery is part of a major new medical study of "regenerative medicine" being pursued by the Pentagon and several of the nation's top medical facilities, including the University of Pittsburgh Medical Center and the Cleveland Clinic. So far nearly $250 million has been dedicated to the research.
Air Force Technical Sgt. Israel Del Toro is one of the wounded vets who might one day benefit from this research. He was injured by a bomb in Afghanistan. Both his hands were badly burned. On his left hand, what was left of his fingers fused together. "You know in the beginning when I first got hurt, I told them just cut it off. So I can get some function," Del Toro said. His doctors did not cut off his injured left arm. And since that injury, advancements in burn and amputation treatment mean he may one day be able to use his fingers again.
A key to the research dedicated to regrowing fingers and other body parts is a powder, nicknamed "pixie dust" by some of the people at Brooke. It's made from tissue extracted from pigs.
The pixie dust powder itself doesn't regrow the missing tissue, it tricks the patient's body into doing that itself. All bodies have stem cells. As we are developing in our mothers' wombs, those stem cells grow our fingers, toes, organs -- essentially our whole body. The stem cells stop doing that around birth, but they don't go away. The researchers believe the "pixie dust" can put those stem cells back to work growing new body parts.
The powder forms a microscopic "scaffold" that attracts stem cells and convinces them to grow into the tissue that used to be there. "If it is next to the skin, it will start making skin. If it's next to a tendon, it will start making a tendon, and so that's the hope, at least in this particular project, that we can grow a finger," Wolf said.
It has worked in earlier experiments. "They have taken a uterus out of a dog, made one in the lab, put it back in, and had puppies," said Wolf. Researchers have also regrown a human bladder, implanted it in a person and it is working as nature intended.
While the technique has incredible promise, doctors will be watching for unexpected side effects as they follow Harris' recovery. "It could grow a cancer," Wolf said. "We will be closely monitoring for that to make sure that doesn't happen."
If the military's most badly wounded start benefiting, so will civilians. "If we can pull this off in missing parts the next step is, 'OK, can we grow a pancreas? Can we grow and replace that in a diabetic?' And can we do the same thing with a kidney and can we do the same thing with a heart?"
One day, he hopes, people with heart trouble will be told, "That's OK. We will just grow you another one.
"That is something that is real science fiction.""
Alright, excitement over.
__________________
Type 1
Dx'd Oct 2, 2006
Medtronic pumper - NovoRapid
Drusens in both eyes.
| 
05-27-2008, 08:23 AM
|  | Senior Member
I am a: Type 1 | | Join Date: Dec 2006 Location: Derby,UK
Posts: 824
| | | Yeah this was in the news some weeks ago, sounds interesting but don't hold your breath.
Azz | 
05-27-2008, 12:59 PM
|  | Senior Member
I am a: Type 1 | | Join Date: Oct 2005 Location: Sacramento California
Posts: 2,515
| | | one problem with type 1's - when we grow back those cells we still have the problem with our immune system attacking and destroying those cells. | 
05-27-2008, 01:59 PM
| | Senior Member
I am a: Type 2 | | Join Date: Apr 2008 Location: Roanoke, VA
Posts: 547
| | | I had read a while back about a doc who was trying to do a transplant of part of a pancreas as a diabetic treatment. Has anyone heard any more about this or how it turned out?
__________________
Janlaton
type 2 40 years
Avandia, Glipzide & Metformin
Grandmother to 4 wonderful children
I have diabetes, It does not have me!
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05-28-2008, 10:15 AM
|  | Senior Member
I am a: Type 1 | | Join Date: Dec 2006 Location: Ontario, Canada
Posts: 1,406
| | Quote:
Originally Posted by BriOnH one problem with type 1's - when we grow back those cells we still have the problem with our immune system attacking and destroying those cells. | Well, possibly yes and no. New theories and research are starting to make it seem like it's not necessarily an immune system thing, or at least not for every T1, so who knows now. Have they actually every proven that's it's an immune system issue? And even if so, how fast would the immune system kill the pancreas? Every 2 years? 5 years? Then you would just need a transplant every so often.
__________________
Type 1
Dx'd Oct 2, 2006
Medtronic pumper - NovoRapid
Drusens in both eyes.
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