Humalog vs Novolog

[GregGolden]

Whats the diffrence between the two?

[spike]

Whats the diffrence between the two?

I don't see enough difference to change any settings on my pump. I'll use eithe one, interchangeably. I expect that someone else might notice some difference and they will weigh in with their thoughts on the matter. (This falls under the realm of YMMV)

[JediSkipdogg]

Novolog supposedly kicks in faster than Humalog. However, it supposely has a longer tail at the end. But the majority is still used up around the same time. Novolog can also withstand heat more, which is why it's recommended for pumps so that it doesn't break down being next to the body heat.

I switched a few months ago from Humalog to Novolog and I made no pump changes and really haven't noticed any difference.

[JasonJayhawk]

I've "heard" that Novolog has a less likely chance of crystalizing in an infusion tube. It's due to the solution in which the insulin is suspended.

The difference between "Novolin" and "Humulin" is entertaining...it's just the solution that they're in, as both are made from the human gene! (If I'm wrong, would someone correct me?)

[spike]

I've "heard" that Novolog has a less likely chance of crystalizing in an infusion tube. It's due to the solution in which the insulin is suspended.

The difference between "Novolin" and "Humulin" is entertaining...it's just the solution that they're in, as both are made from the human gene! (If I'm wrong, would someone correct me?)


but, but, but I've been running my sets for 3 days for 10 years and don't think I've had crystalllized insulin. If I had, it couldn't have been more than 3-4 times when I had a no delivery alarm, but even those were mostly issues at the infusion site, rather than in the line. I just can't get behind the notion of a big problem with crystalization. Anyone else have a PROVABLE case of this phenonenom? ie somthing other than "I heard about someone who..."?

[jeggeman31]

I changed from Humalog to Novolog a few months ago. The only difference I have seen is a cheaper Co pay.

[JasonJayhawk]

Here's where I remember reading about it, but it's still only hearsay:

http://www.childrenwithdiabetes.com/dteam/2002-10/d_0d_9lw.htm

[am1977]

I've switched from Humalog to Novolog and haven't seen much of a difference either :thumpdown... though i was hoping it would, ultimately, improve my control :frown:

[spike]

Here's where I remember reading about it, but it's still only hearsay:

http://www.childrenwithdiabetes.com/dteam/2002-10/d_0d_9lw.htm


hmmm...there wasn't much to read on that link.

[David]

There's differences in how the amino acids are sequenced. In Humalog the positions of two amino acids, lysine and proline, are reversed while in Novolog, the B28 amino acid, normally proline, is replaced by aspartic acid.

That's what affects their action profiles the most. The specific amino acid sequences are also what makes Apidra, Lantus and Levemir act like they do, so I wouldn't be surprised for there to be some differences between Humalog's and Novolog's action.

Here's also something about the different sources (not the effects) of insulin analogs, you'll have to scroll down to pg 11, 12 and 13.

http://www.wiley-vch.de/templates/pdf/352731184X_c01.pdf

Note that Humalog and Apidra are produced in E. coli while Novolog comes from S. cerevisiae

Maybe it's TMI, but there's more info here too:

http://en.wikipedia.org/wiki/Insulin_analog

https://secure.pharmacytimes.com/lessons/200510-03.asp

David