The genetics of type one

[E-NICE]

I have not heard of any research lately into the genetics of type one. Like what gene or genes make a person predisposed to becoming one? What is their action in connection with autoimmune responce? It Just seems to me that any cure that would be permanent would have to deal with these issues. Bad genes are what got alot of us in this mess in the first place. Anyone who has any knowledge of this their input would be appreciated.

[rzrbks]

:topic:

to find the correct gene

Start here(near Gladstone Park, London)>>>>>>>>> Google Maps (http://www.google.com/maps?ie=UTF-8&oe=UTF-8&hl=en&tab=wl&q=)

Take Edgeware Rd to the M1 then just past Aldenham pick up the M25 til you get to M40 follow that until that turns into the M42 then use M42 until the M5, M5 to M6, M6 to A74(M), A74(M) to A71, A71 to A738, A738 to A737, A737 to M898, M898 to A898, A898 to A82, A82 to A9, A9 until you come to Thurso, park your car at the corner of Paterson's Ln and Barrock's St.

Voila Vous êtes là, Version premier.

[E-NICE]

Did not mean to get off topic. Just was curious because type one runs very strong in my family and already has killed serveral relatives before me. This is of great concern to me since me and my wife plan on starting a family soon and was just looking for some information.

[seacomp]

Type 1 is partially genetic, less so than Type 2. Certain genes can be identified that put you a quite high risk level. But not everyone with those genes gets Type 1, and many who get the disease don't have the gene. Usually an infection starts off the auto-immune reaction.

[E-NICE]

Those genes that put you at high risk for type one. Has any research been done into why they put a person at high risk? What these genes do or dont do? And for they type ones that have their illness triggered by an infection what is it about some infections that they cause the immune system to attack the beta cells? And is there someting in their makeup other than the known genes that put them at risk?

[seacomp]

Those genes that put you at high risk for type one. Has any research been done into why they put a person at high risk? What these genes do or dont do? And for they type ones that have their illness triggered by an infection what is it about some infections that they cause the immune system to attack the beta cells? And is there someting in their makeup other than the known genes that put them at risk?
The think all the questions except what the genes do and still open. No one yet knows the answer. Actually they might only know that those genes are active in the Beta islet cells of the pancreas.
To clarify, it is an inherent variant of the identified genes that are associated with T1.

[SueM]

You might find some info here
Genetic Types of Diabetes including Maturity Onset Diabetes of the Young (http://www.projects.ex.ac.uk/diabetesgenes/)
If you email prof Hattersley he will give u plenty of info too he's a very nice person.

[seacomp]

You might find some info here
Genetic Types of Diabetes including Maturity Onset Diabetes of the Young (http://www.projects.ex.ac.uk/diabetesgenes/)

I'm glad someone has a direct source. I've read that stuff but I don't retain the particulars.

[SueM]

I'm glad someone has a direct source. I've read that stuff but I don't retain the particulars.

It just so happens I see a consultant at Exeter so follow with interest what is going on. :)

[E-NICE]

Genes Can Cause Type 1 Diabetes (http://www.genetichealth.com/DBTS_Genetics_of_Type_1_Diabetes.shtml)

[DeusXM]

It just so happens I see a consultant at Exeter so follow with interest what is going on.

Peninsular Medical School/RD+E?

If you're down there with them then you're very lucky. When I was at Exeter the team there were absolutely fantastic and I'd have no hesitation in saying they are the best people in Europe, possibly the world, to see about diabetes.

[MJM]

I have not heard of any research lately into the genetics of type one. Like what gene or genes make a person predisposed to becoming one? What is their action in connection with autoimmune responce? It Just seems to me that any cure that would be permanent would have to deal with these issues. Bad genes are what got alot of us in this mess in the first place. Anyone who has any knowledge of this their input would be appreciated.

I'm not sure whether I heard it or read it but there is some research into testing genes in infants and possibly being able to replace defective ones. If that is true it would be tremendous for possible future type1's. My memory is too sketchy to be sure on this though.

[rzrbks]

I'm not sure whether I heard it or read it but there is some research into testing genes in infants and possibly being able to replace defective ones. If that is true it would be tremendous for possible future type1's. My memory is too sketchy to be sure on this though.

Oopsie, that'll get you banned from the Good Ol' You Ess of A, taking about gene therapy and cell research.