Faster Insulins?

[Injecto]

To anyone's knowledge, are any companies out there actually working on faster insulins? Meaning, with a faster profile, peaking slightly earlier, and not lasting as long in the body?

If so, who? Any expected time frame for such a release?

[JediSkipdogg]

I have not heard of any and all 3 major companies have a fast insulin out there. I think the major part of what slows it down is the fact that it has to go through fat. I know in trials with implantable pumps they have used R in them and they work almost just as fast as a non-diabetic. So the major issue to get by is dealing with fat.

[Scratch]

I believe that Viaject (http://www.medicalnewstoday.com/articles/75038.php) is the most likely candidate to peak faster and clear from the body quicker.

[JediSkipdogg]

I believe that Viaject (http://www.medicalnewstoday.com/articles/75038.php) is the most likely candidate to peak faster and clear from the body quicker.

Why oh why is everything always compared to R? That's what drives me nuts, heck, everything is faster than R. I hadn't heard of Viaject yet, interesting.

[Scratch]

Why oh why is everything always compared to R? That's what drives me nuts, heck, everything is faster than R. I hadn't heard of Viaject yet, interesting.
If you do a search for Viaject, you started a thread on it!

Yeah, it's hard to judge, but it's faster than R obviously, and looks to be slightly faster peaking and clearing than Huma/Novolog/Apidra analogues.

There also may be fewer concerns about mutagenic properties with the formulation as well.

[JediSkipdogg]

If you do a search for Viaject, you started a thread on it!

I did? LOL...musta been one I found by accident. I'm just use to paying attention to Eli Lilly, Novo Nordisk, and Aventis for insulins

[notme]

Scratch can you explain a bit more on the "mutagenic properties" that they are concerned about? I looked online, but couldn't find anything. Do they mean mutagenic properties in mice or in the insulin itself?

[Scratch]

Scratch can you explain a bit more on the "mutagenic properties" that they are concerned about? I looked online, but couldn't find anything. Do they mean mutagenic properties in mice or in the insulin itself?
There are some concerns that the insulin analogs due to their structure may have mutagenic properties, that prolonged exposure may over time be cancer causing. The evidence isn't very clear so far as I can tell, and it's no guarantee that just because Viaject might have a "more natural" structure that it can't be mutagenic as well. Plenty of natural things can cause cancer too.

[notme]

Thanks for the explaination. :)