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View Full Version : Resistance, Metformin, steroids, and craziness


caryncorn
10-27-2007, 06:17 PM
Let me take a second to introduce myself first: I'm Caryn, diagnosed type 2 in 1998. Controlled strictly by Metformin until 2 years ago when gallbladder surgery caused extreme gastritis. This caused me to go off the Glucophage and nothing else was working for me. My A1C creeped up from the mid 5's to 7.3 over the last year. I started on insulin in June of this year and started pumping in July (I had pumped during pregnancy and was very clear that if I ever had a need for MDI's again that I would want to pump).

Fast forward to September...A1C is 6.3 and expect my results from my endo visit in October to put me in the 5.2 range.

With lots of work and medicine, I have gotten my gastritis back under control to the point where I wanted to try the Metformin again to deal with the insulin resistance. Current TDD is around 150 units a day (Humalog).

Okay, got sick last week and had to go on Prednisone. Bumped my basal up 350% and gradually weaned it down during the 7 day course of steroids. I also started on the Metformin at the same time.

I'm off the steroids for 2 days now and am currently running my basal at 30% of it's usual dosage (yesterday, I tried 50% and could not get blood sugars out of the 50-60 range all day).

I am also experimenting with my insulin:carb ratio (currently 1:3 but changed to 1:4) this evening to see what happens. Last night I was running so low that I eventually just disconnected from the pump. I woke up with a fasting of 126 and reconnected.

Anyone else have similar experiences with Metformin making such a DRASTIC and sudden impact on insulin needs? I'm floored here and wondering if after all is said and done that I'm going to be able to get back into control with just 1000 mg of Metformin (that's the max my endo wants to go because of the gastro issues).

I ate so much sugar yesterday that I felt like puking!!! Is this a honeymoon kind of thing? Shouldn't my blood sugars still be elevated from the steroids (I seem to remember it usually taking a couple of weeks to return to normal)?

Any thoughts?

EasyType2
10-27-2007, 09:01 PM
Caryn, my experience ( two incidents ) with steroids is that it does take up to a week for them to clear our system, and allow us back on a routine that once worked.

I advise you hold off at least another week before making a big decision on meds/pumping.

I'm also a T2, and my BGs usually run up and down like a yo-yo, even on the same diet/med/activity regimin. My endo told me that was a frequent aspect of Type 2.