Rekarb
07-23-2009, 02:12 PM
You guys are going to love this one.
I just got back from seeing my endo and I wanted to talk about my results. He dx'd me as a LADA but I tested negative for all antibodies with a 1.56 c-peptide. I'm black, 56 and until a few months ago, the picture of health.
What I wanted to talk about was the chance that I had "Atypical KPD". These are people who suddenly present with very high bg, are treated with insulin but then gradually become insulin independent and are then treated as t2's.
He noted that since the treatment for me as a LADA was the same for the Atypical KPD that the out come would tell what I was.
We are use to using the term LADA and 1.5 interchangeably but these Atypicals can and do go back and forth across beween being insulin dependent and insulin independent.
Hey, I'm not making this up!
http://www.ncbi.nlm.nih.gov/pubmed/15579799?log$=activity
Atypical ketosis-prone diabetes (http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2592328)
From what I'm reading and from what the endo told me, most of these people were initially given a t2 dx and wound up in emergency with very high bg. After the bg was stabilized for a time, they went back to making there own insulin. Some. of course relapsed, some didn't. Some relapsed and still went back to being insulin independant.
The theory, from what I understand, is that high bg incapacitates the Beta cells. As this situation continues the bg worsens and a deadly spiral results. If normal bg is restored the Beta cells come back online and maintain relatively normal bg.
The really bad part for people with this is that most appear to be almost classic T2's but treating them initially as T2's could have very dire consequences.
I might be one of these types - I might not. Time will tell but I'm definitely keeping my 1.5 t-shirt.
Mike
T1.5 and proud
I just got back from seeing my endo and I wanted to talk about my results. He dx'd me as a LADA but I tested negative for all antibodies with a 1.56 c-peptide. I'm black, 56 and until a few months ago, the picture of health.
What I wanted to talk about was the chance that I had "Atypical KPD". These are people who suddenly present with very high bg, are treated with insulin but then gradually become insulin independent and are then treated as t2's.
He noted that since the treatment for me as a LADA was the same for the Atypical KPD that the out come would tell what I was.
We are use to using the term LADA and 1.5 interchangeably but these Atypicals can and do go back and forth across beween being insulin dependent and insulin independent.
Hey, I'm not making this up!
http://www.ncbi.nlm.nih.gov/pubmed/15579799?log$=activity
Atypical ketosis-prone diabetes (http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2592328)
From what I'm reading and from what the endo told me, most of these people were initially given a t2 dx and wound up in emergency with very high bg. After the bg was stabilized for a time, they went back to making there own insulin. Some. of course relapsed, some didn't. Some relapsed and still went back to being insulin independant.
The theory, from what I understand, is that high bg incapacitates the Beta cells. As this situation continues the bg worsens and a deadly spiral results. If normal bg is restored the Beta cells come back online and maintain relatively normal bg.
The really bad part for people with this is that most appear to be almost classic T2's but treating them initially as T2's could have very dire consequences.
I might be one of these types - I might not. Time will tell but I'm definitely keeping my 1.5 t-shirt.
Mike
T1.5 and proud