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View Full Version : Accelerator hypothesis -- T1, T2 and all between ... !

foxl
07-31-2009, 02:20 PM
accelerator hypothesis - Google Search (http://www.google.com/search?hl=en&q=accelerator+hypothesis&aq=f&oq=&aqi=g1)

In many ways, we are not so different, eh? I am very interested in this!
Scratch
07-31-2009, 02:26 PM
I'd need see a lot more to understand how they are developing this hypothesis as an explanation of the evidence.

My own statistical example of 1 -- I was always skinny. Skinny. As in very skinny. As in there were no outward manifestations of an insulin resistant metabolism, so far as I know. But I may simply be lacking data, perhaps if my blood had been drawn when I was below the age of 15 I would have seen extremely high c-peptide values and that large amount of native insulin is what spawned the autoimmune attack.

I've had some conjecture and thinking of my own in the past that type 2 may well be autoimmune of some form, but not of the same triggers and form as type 1.

I look at what I know in terms of evidence and I don't find the accelerator hypothesis compelling.
foxl
07-31-2009, 02:29 PM
Scratch clearly there are other skinny persons here too ... and this is a population study --- not about individuals but population trends!

It fits me, though. Clearly. I had the inactivity and weight gain prior to diagnosis, but not all the symptoms of full-blown metabolic syndrome ... and had pre-existing autoimmune thyroiditis. Wish I had been made aware of the increased risk of D for my situation.

Testing the Accelerator Hypothesis ? Diabetes Care (http://care.diabetesjournals.org/content/26/10/2865.full)
foxl
07-31-2009, 02:43 PM
Wow -- apparently from the number of google links, this is a BIG debate.

MY only question involves insulin use in Type 1's who have NO C-peptide, yet need a relatively low TDD of insulin. How do you justify their existence, if "all diabetics" have a disease of insulin resistance? We know you are out there ... right? So it seems kind of irrational, to me!

What do you all think?
foxl
08-01-2009, 08:07 AM
Bumping ... am I really the only person who finds this theory to be of interest? The more I read, the more I like it! And my original take on it may not be accurate -- any of three factors in combnation lead to the condition of D -- it is more an explanation of the recent increase, than individual cases.
jenb
08-01-2009, 06:36 PM
Thanks for the link. Interesting, but how to account for people like me: 5 lbs 7 oz at birth, yoyo weight most of life, developed T1 at age 53. No insulin resistance - my TDD of basal and bolus is 24 to 28 units. I and many others certainly do not seem to fit the study model.

Jen
foxl
08-01-2009, 06:55 PM
Thanks for the link. Interesting, but how to account for people like me: 5 lbs 7 oz at birth, yoyo weight most of life, developed T1 at age 53. No insulin resistance - my TDD of basal and bolus is 24 to 28 units. I and many others certainly do not seem to fit the study model.

Jen


I suspect the way the article as written is too sweeping in its claim. But I can definitely see D being a combination o the three possibilities, in varying amounts. A sort of Venn diagram thing, with some people in the single circles, and others in overlapped areas?
jenb
08-03-2009, 10:26 AM
Linda - you are right, of course, about the over-broad interpretation represented in the article. Unfortunately, many people, including physicians, will read this and draw incorrect conclusions, leading to further misunderstanding of the complex nature of T1 and incorrect diagnosis and treatment for people with late-onset. A little knowledge is a dangerous thing ;) .

Jen
foxl
08-03-2009, 10:36 AM
Linda - you are right, of course, about the over-broad interpretation represented in the article. Unfortunately, many people, including physicians, will read this and draw incorrect conclusions, leading to further misunderstanding of the complex nature of T1 and incorrect diagnosis and treatment for people with late-onset. A little knowledge is a dangerous thing ;) .

Jen


TRUE. This article was from 2001 though, so it has been out there for eight years ... many published since are all over the place!

Particularly in searching on LADA, there is a huge range of theory (all presented in the same black-and-white way) whether "all" LADA must have a component of insulin resistance (or sometimes, metabolic syndrome) or not. I find the literature very confusing on this, as each author has their pet theory and stands staunchly by it ... instead of accepting a range of possible causes. This is not telling me doodly squat about practical managment, obviously, but it is interesting!
notme
08-03-2009, 05:00 PM
Thanks for the link. Interesting, but how to account for people like me: 5 lbs 7 oz at birth, yoyo weight most of life, developed T1 at age 53. No insulin resistance - my TDD of basal and bolus is 24 to 28 units. I and many others certainly do not seem to fit the study model.

Jen


I really don't fit the model either jenb. I was normal weight all of my life, had five children with no gestational diabetes. I was always active and healthy. Lost about 30 pounds in a month in a half and was diagnosed with type one diabetes in the hospital at that time.

Not sure about this study, but will keep reading.