New diet meds for diabetics???????

[Belinda]

Has anyone heard or tried the new meds that they give diabetics to help lose weight? It starts with an s...I am sorry that I don't have more info but I am out of town and the name is at home. Anyways, it is something that are pancreas produces and being diabetic we don't have it. It is suppose to help when you eat. (since I don't eat too much and can't seem to lose weight). It will also decrease the amount of insulin you take by 1/2. The drawback is that it is by injection. Just wanted to know...has anyone tried it? if so what do you think? or anyone heard about it? since I am the true optimist..... :whistling I will be beginning the injections on Sunday when I get back into town. I will try anything that will help me or that my doctor thinks will. I went to LA weight loss and he said...NO don't do that lets try this since we have exhausted lots of other options. So forum family...if no one else has tried it and I am the first .....I will post about it just in case others may want to try. There is 2 different kinds of injections. One for T1 and one for T2. Here is looking at another medical breakthrough.... :D

[HeatherP]

I think you're thinking of Symlin. It's an injectable complimentary hormone (to insulin) that helps control after-meal b/s's and is supposed to help us lose weight.

[archimeech]

that's the new artificial lizard spit. they've found an enzyme in the saliva of the Gila Monster.

[jeggeman31]

I think you're thinking of Symlin. It's an injectable complimentary hormone (to insulin) that helps control after-meal b/s's and is supposed to help us lose weight.

I seen something one day on this, can we get it now, or is it still waiting to be approved by the FDA ?

[HeatherP]

I do beleive it's available this month. Diabetes Health mag did an article on it in their June issue. www.symlin.com Symlin is for T1 and T2 Diabetics.

The lizard spit is Byetta which is also an injectable. www.byetta.com Byetta is for T2's. There will be a feature article in Diabetes Health July issue.

[jeggeman31]

I do beleive it's available this month. Diabetes Health mag did an article on it in their June issue. www.symlin.com Symlin is for T1 and T2 Diabetics.

The lizard spit is Byetta which is also an injectable. www.byetta.com Byetta is for T2's. There will be a feature article in Diabetes Health July issue.

Thanks for the info Heather

[HeatherP]

You're very welcome! :thumbsup:

[Belinda]

Yes!!!! that is it and you can get it now....I could have picked mine up today but I am out of town and have to wait until....SATURDAY....

[am1977]

Belinda, I hope you will keep us updated on how it works for you...I know I am interested ;)

Keep us posted :)

Thanks,

Andrea :nerd:

[duck]

...Be careful, from what we discussed before it's not a "diet aid" but rather an insulin potentiator--a POTENT potentiator (redundancy, I know).

[Harold]

Kinda of looks like they are very similar in that they are both from the Exenatide family, if I am reading this right. Besides the other two appear to be in Phase II trials. 2. GLP-1 Analogues: A new class of injectable anti-diabetes therapies that mimic
natural GLP-1 normally produced by the body. The protein structure of GLP-1
analogues is slightly different than natural GLP-1, which slows their breakdown by
the DPP-4 enzyme and extends their effect in the body. The GLP-1 analogues are
intended to increase the level of GLP-1 in the bloodstream and enhance the effect
on glucose control. The first analogue was recently approved, and a number of
others are under investigation. Those being tested for the treatment of type 2
diabetes include:
· Exenatide (Amylin/Lilly) — Exenatide is a twice-daily injection for the
treatment of type 2 diabetes that was approved by the FDA in April 2005.
Exenatide is a synthetic version of exendin-4, a hormone in the saliva of the Gila
monster, a lizard native to several southwestern American states. It displays
properties similar to human GLP-1.
· Liraglutide (Novo Nordisk) — Liraglutide is a once-daily injectable GLP-1
analogue in Phase II trials. The compound decreases the level of glucagon.
During preclinical testing, Liraglutide (NN2211) increased the ß-cell mass in
animal models of type 2 diabetes, leading to speculations about its potential
ß-cell regeneration capacity.
· DAC:GLP-1 (ConjuChem) — DAC:GLP-1 is a GLP-1 analogue currently in Phase II
clinical trials for the treatment of type 2 diabetes. Recent trial results demonstrated
that DAC:GLP-1 reduced glucose levels in patients in a statistically significant manner
(at all times of the day, including the morning fasting period), has a long duration of
activity, and has been shown to be safe and non-immunogenic in all clinical testing
to date.
They are the first of the Incretin Hormone GLP-1 Analogues. The Incretin Hormones are just part of the chemical signals that our bodies use to control glucose and insulin levels. Appetite supression is one of several effects considered a secondary or also effect. Incretins also have been shown to have several other important effects:
· Increased ß-cell growth and mass, which may help maintain insulin production and
slow the progression of type 2 diabetes.
· Delayed gastric (stomach) emptying, which slows the rate at which nutrients are
absorbed in the intestines, potentially helping stabilize blood glucose levels.
· Appear to be active in the brain, affecting satiety (feeling full) and regulation of
food intake.
The above two Quotes come from aace.com (http://www.aace.com/pub/emerging/Incretin_Hormones_Fact_Sheet.pdf) whic is a PDF file. Which I linked to in my Post (http://www.diabetesforums.com./showthread.php?t=5309). Should have made that post in the common Diabetes forum, and since Incretin Hormone drugs are for treating Diabetes, not a complication, I think I will take the liberty of moving this thread there. :hypocrite

[Belinda]

Don't worry I will be careful, my doc told me about how it will reduce my insulin intake etc......he knows how "anal" I can be about meds and new things and that I will dilligently keep records etc....if it doesn't work or causes me any trouble...he also knows I will call and tell him that I will not be taking this anymore....I will keep the "family" posted. :thumbsup:

[Lorna]

Does anyone know when this will be available in the UK?

[Belinda]

Day one....no symptoms....had only one low of 68 which to me is my normal Sunday BS at about 11. If no symptoms tomorrow I will increase the dose. Boy having to inject again is not fun but it is like riding a bike :whistling

[Belinda]

Day five and I have increased the intake per doc's orders from 205 to 5.0 units. The big difference is that I use about 10 units less of insulin a day and my BS is staying at a more level stage...no high peaks after meals. I also eat about 2 meals a day and that is it...Wonder what is going to happen by the time I get to the recommended 10 units?

[amyjean]

I have been waiting for Symlin to hit the market because I would like to try it also. I guess I need to call my doctor monday to see about getting on it. Does insurance cover ir? Is it costly? I hope you don't mind me asking. Keep us posted on your progress.

Thanks, Amy

[Belinda]

My insurance covered it..got 6 vials (500 units per) for 40.00 since it is a new drug and not generic...

It has really cut down on my insulin by 10 units and I am not even up to the full dose yet, also I eat lots less and the BEST part is....my BS is always hovering around 100 or lower...(sometimes before it would go up drastically after some meal but not always :confused: so this has helped alot for me...we will see when I go back in Sept of the real results. (that is doctors...but I plan on doing a home A1C test in about 6 weeks after I get to the full dose)

[amyjean]

Belinda,

Thanks for the info on insurance and cost. I am so excited it is out. I am going to call my doctor monday.

Thanks, Amy

[kcope]

I will be starting Byetta today.

[Belinda]

I have been on a full dose for a week now and have notice that I take 10 units less of insulin now I only take about 20 a day. :rock: . I also noticed my appetite has decreased to about half as well. As for the severe lows, it took some practice but just have them occasionally. I do a dual bolus now for everything and that has helped tremendously.

[duck]

I have been on a full dose for a week now and have notice that I take 10 units less of insulin now I only take about 20 a day. :rock: . I also noticed my appetite has decreased to about half as well. As for the severe lows, it took some practice but just have them occasionally. I do a dual bolus now for everything and that has helped tremendously.

A bolus of insulin or amylin/smylin whatever-it's-called?

[amyjean]

I started taking Symlin about five days ago and it has also decreased my insulin use by about 7 units. I am not at the highest dose aloud yet. I have also found I can't eat as much as I used to. It does make me feel sick to my stomach at times. I am excited though and hope I am able to decrease my insulin even more.

thanks, Amy

[Belinda]

A bolus of insulin or amylin/smylin whatever-it's-called?
Dual bolus for the insulin. This way I get it some up front and then some over a set period of time. :flybye: