What is type 1.5?

[Lynne1]

What is type 1.5?

[TvBabe]

What is type 1.5?


The following URL might explain it alot better than I could :)

http://www.diabetesnet.com/diabetes_types/diabetes_type_15.php

[jeggeman31]

The following URL might explain it alot better than I could :)

http://www.diabetesnet.com/diabetes_types/diabetes_type_15.php


And a heck of alot better than me :pcguru:

[Lynne1]

Thanks. I wonder if C-peptide levels are lower in type 1.5s? Never knew about this. I'll ask my endo...although my triglycerides are through the roof. My bp is ok, though.

[lelggren]

Thank you for asking that question! I was wondering the same thing when I first joined this forum. This is the first place that I have ever heard of it. I'll look at that site that was listed. Thanks again! :ciao:

[seacomp]

As far as I know, the definitin given above for 1.5 is perfectly correct. I personally use the term, to reflect the fact that I am a Type II who is now insulin dependant. This does not meet the definition, but I wanted to signify that I have characteristics of both.

[Simon]

As far as I know, the definitin given above for 1.5 is perfectly correct. I personally use the term, to reflect the fact that I am a Type II who is now insulin dependant. This does not meet the definition, but I wanted to signify that I have characteristics of both.

That might explain why so many people on the forum claim to be type 1.5 when it's actually quite a rare form. I must admit I'd never heard of it either until I was told I was one.

[Lynne1]

Thank you for asking that question! I was wondering the same thing when I first joined this forum. This is the first place that I have ever heard of it. I'll look at that site that was listed. Thanks again! :ciao:

No problem. I didn't know if 1.5 was a poopy pancreas or a combo of types 1 & 2 or what. Interesting.

I pretty sure I'm a type II with a poopy pancreas...runs in my family.

[seacomp]

a poopy pancreas...runs in my family.
Sounds messy.

[duck]

Ocassionally news media will post articles about the raging debate in the medical community about how many distinct "Types" of diabetes there really are...For decades it was Type 1 or Type 2, now Type 1.5 is getting serious consideration, as is "pre-diabetic" and a number of possibilities "between" Type 1 and Type 2. If I run across another, I'll post it.

At least they are researching this stuff...

[Lynne1]

Sounds messy.

LOL!!!:laugh: :laugh: :laugh: :hahaha:

[rea]

I knew I had LADA, but I never new it was refered to as 1.5.
For the longest time they thought I was a MODY, as I never fit quite into either category 1 or 2.

there is very little documentation on LADA out there. if anyone knows of any other articles, please post them.

[sydneya]

I knew I had LADA, but I never new it was refered to as 1.5.
For the longest time they thought I was a MODY, as I never fit quite into either category 1 or 2.

there is very little documentation on LADA out there. if anyone knows of any other articles, please post them.

All these initials drive me bananas. What does MODY stand for. (I know I'm taking a chance asking. I'm usually humbled by someone giving a real simple everybody knows answer.)

[Lynne1]

I don't understand what the acronyms are either.:dontknow:

[Funnygrl]

There are two types of 1.5. LADA is latent autoimmune diabetes of adults. That's what I have. LADA is basically type 1, but with an older diagnosis age, and the diabetes onset is gradual rather than fast with type 1. LADA people are often diagnosed type 2, then changed to type 1, since at first they have higher blood sugars and normal c-peptides, then the c-peptide level drops.

MODY is another type of 1.5. MODY stands for maturity onset diabetes of youth. This is similar to type 2, but it diagnosed in kids and is genetic rather than lifestyle linked. There are various forms of this, some requiring constant insulin, some requiring intermittent insulin, some never requiring insulin.

[Funnygrl]

No, that's not at all what type 1.5 is. People with LADA show almost no characteristics of type 2, they are not usually overweight, nor can they be controlled by diet and exercise. They are more like type 1. People with MODY also are rarely overweight.

Type IIs who are on insulin does not make a person type 1.5. When a person with type II diabetes requires insulin it is termed beta cell exhaustion, meaning their pancreas just can't keep up with the insulin resistance and the higher blood sugars.

Insulin resistance is the key characteristic of type II, where it is not at all associated with LADA (I'm actually extrememly insulin sensitve) and not always associated with MODY.

Type 1.5 is not rare, it was just never heard of before so the person was diagnosed as type 1 or 2, depending on what they were closer to, or as mentioned in my above post, was dx'ed type 2 then changed to type 1.

You will notice the people here who are type 1.5 are often fairly recently dx'ed. In the past the necessary testing (c-peptide, anti-bodies) just wasn't availible.

[rea]

thats right.

They had a hard time diagnosing me until they did a c peptide (took months to get results), and realized I dont produce very much insulin, and have produced less and less over time. (hence slow progression of type one).

its often diagnosed as type two, which was what happened to me. excersize never worked with diet alone for me- alhough I did loose weight, it never improved my blood sugars to make much difference.

then they thought I had mature onset of the young (MODY) until they looked at insulin production. I still have one specialist who will argue I am a MODY.

It gives you a real lab rat feeling.

either way, i guess it doesn't matter what you are, (as my doctor reminds me) as long as they can treat the problem so you can carry on with your life.

If next week the doc starts calling me an ABCD.5 , I won't care, as long as I can find a way to manage my blood sugars.

[JasonSmithMT]

Because there is a nice reminder at the top of the forum that says I haven’t posted in several weeks at the top of the form :( I thought I would chime in …

Diabetes classification seems to be confusing to a lot of people. The bottom line, as Rea says, is that it doesn’t really matter what you and/or clinician calls you as long as you get appropriate therapy.

Part of the problem is that in the past diabetes classification wasn’t based on the underlying pathophysiologic mechanism as it is today but based on things such as age (juvenile vs. adult) or treatment (insulin vs non-insulin) for example.

According the current World Health Organization (WHO) and American Diabetes Association (ADA) classification schema there are four types of diabetes: type 1, type 2, gestational, and secondary diabetes (other forms of diabetes).

Type 1 is a primary result of beta cell destruction. This can be as result of an autoimmune process (type 1A) or in very rare cases a non-autoimmune process (type 1B or idiopathic.)

Type 2, the most common type of diabetes, is a result of insulin resistance or insulin secretory defect.

Gestational diabetes is diabetes that is diagnosed during pregnancy.

Secondary diabetes is specific types of diabetes that is considered neither type 1 nor type 2. These includes things like genetic defects in beta cell function (MODY 1 through 6), genetic defects in insulin action (leprechaunism, Rabson-Mendenhall syndrome, etc.), exocrine pancreatic diseases (pancreatic cancer, hemochromatosis, pancreatitis, etc.), endocrinopathies, drug or chemical induced diabetes, among other things.

Type 1.5, or LADA (latent autoimmune diabetes in adults), falls in the current classification schema as a Type 1 that has a slow onset.

Maturity onset diabetes of the young (MODY) falls in the classification as secondary diabetes because specific genetic mutations causes the primary defect in beta cell function.

Jason

[TvBabe]

Secondary diabetes is specific types of diabetes that is considered neither type 1 nor type 2. These includes things like genetic defects in beta cell function (MODY 1 through 6), genetic defects in insulin action (leprechaunism, Rabson-Mendenhall syndrome, etc.), exocrine pancreatic diseases (pancreatic cancer, hemochromatosis, pancreatitis, etc.), endocrinopathies, drug or chemical induced diabetes, among other things.

Jason

Hemochromatosis actually triggered my diabetes, and since my endo has done several C Peptide tests on me she believes I am type 1.5. Although as you can see by my signature she's still not sure....my next C Peptide test might define me :)

I have read and spoken to other HH/Diabetics and many of them have been classified as type 1.5 with C peptide tests.

[JasonSmithMT]

Hemochromatosis actually triggered my diabetes, and since my endo has done several C Peptide tests on me she believes I am type 1.5. Although as you can see by my signature she's still not sure....my next C Peptide test might define me :)

I have read and spoken to other HH/Diabetics and many of them have been classified as type 1.5 with C peptide tests.

I'm not sure why they would be called type 1.5 instead of the secondary diabetes. :dontknow: HH, as you are unfortunately all too aware of, can damage beta cells which would indeed lead to a decrease in C peptide levels and is quite common in those who have HH with a resultant secondary diabetes.

Jason

[sydneya]

There are two types of 1.5. LADA is latent autoimmune diabetes of adults. That's what I have. LADA is basically type 1, but with an older diagnosis age, and the diabetes onset is gradual rather than fast with type 1. LADA people are often diagnosed type 2, then changed to type 1, since at first they have higher blood sugars and normal c-peptides, then the c-peptide level drops.

MODY is another type of 1.5. MODY stands for maturity onset diabetes of youth. This is similar to type 2, but it diagnosed in kids and is genetic rather than lifestyle linked. There are various forms of this, some requiring constant insulin, some requiring intermittent insulin, some never requiring insulin.

Thank you for the thorough explanation. There are so many types of diabetes now. I'm from the old school when there was Type I and Type II. It's amazing ow much there is to learn in life.

[seacomp]

Part of the problem is that in the past diabetes classification wasn’t based on the underlying pathophysiologic mechanism as it is today but based on things such as age (juvenile vs. adult) or treatment (insulin vs non-insulin) for example.


These explanations have been quite good and I've learned alot. But Jason brings up a point, which maybe he didn't know he was bringing up, that a classification system is relevant to what you are going to use it for, not some definition hanging in the sky.

I am an ordinary, insulin resistant, Type II who has progressed to the point of being dependant on injected insulin. From a disease standpoint, I'm strictly T2.

But, from an experience and issues standpoint, I have gone through everything that Type II's do, and most of what Type I's do. Until the forum adds a classification, such as, "Type II, insulin", I'm a 1.5 for the purposes of the forum.

[stella117]

I was recently diagnosed as type 1.5. I think that my advanced age at the time of diagnosis (most type 1s are diagnosed as children/teens) and the fact that I am insulin sensitive, not insulin resistant and insulin dependent not insulin deficient is why I'm classed not quite as one, but definitely not two. Personally, I think that 1.5 is actually type 1, but that it occurs later and sometimes is misdiagnosed as one when the person still has some basal cell functioning.

I believe I was diabetic (hyperglycemic) for over a year before diagnosis. But because I had some pancreatic function, the symptoms didn't kick in until later. If I had been going to a doctor regular and getting annual physicals/blood tests, they would have caught it much sooner and probably diagnosed and treated it as type 2--which might have preserved my pancreas a little longer.

As it happens, it wasn't until 4-5 months before I got diagnosed that the symptoms starting kicking in (and I had just about ALL of them!) which prompted me to seek medical treatment.

[Funnygrl]

People will better understand what you are trying convey using the term 1.5 if you put that info in your signiture rather than just classifying yourself as 1.5.

[Harold]

I'm from the old school when there was Type I and Type II. It's amazing ow much there is to learn in life.

"Classes" of diabetes in 1894 (http://www-unix.oit.umass.edu/~abhu000/diabetes/tidbits.html)

An excerpt from a letter written in 1894 to the Mayor of New York City by Cyrus Edson, the Commissioner of Health. It was published in a popular journal called Overland Monthly and Out West Magazine. Most of the letter discusses the "wholesomeness" of glucose (grape sugar) compared with sugar derived from cane sugar, apparently a major issue in the late 19th century. Below is that part describing diabetes and his view of its two types.

"...In addition to certain nervous varieties, due solely to disturbed nerve functions, diabetes is divided into two classes, of which one is due to excessive sugar formation in the blood and the other to diseased digestion, which prevents sugar from entering the circulation in the condition to be utilized by the system. The first of these classes is caused by disease of the liver; the second by disease of the pancreas. The latter form is by far the most dangerous and rapidly fatal. The former variety, on the other hand, may last many years."

[Harold]

Until the forum adds a classification, such as, "Type II, insulin", I'm a 1.5 for the purposes of the forum.Not likely to happen. Type I and Type II are really Outmoded classifications that caused a lot of people to be medicated in the wrong manner, resulting in too many complications and deaths.

From David Mendosa (http://www.mendosa.com/)

Incorrect Diabetes Terms (http://www.mendosa.com/incorrect_terms.htm)

Outmoded terms for forms of diabetes are still in use. What used to be called juvenile diabetes or insulin-dependent diabetes mellitus (IDDM) is now correctly referred to as type 1 diabetes. The former terms, adult-onset diabetes or non-insulin dependent diabetes mellitus (NIDDM), are now properly called type 2 diabetes. It is type 1 and type 2, not Type 1 or Type I and Type 2 or Type II. And there is no such thing as borderline diabetes. If that’s what you think you have, it is either pre-diabetes or diabetes. And forget about calling either condition sugar diabetes, and the pills that you might use to treat diabetes are not sugar pills.

For those that like to refer to themselves as Diabetic, please read the second paragraph. Looks like there is one user name still open. :cool: