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11-12-2007, 06:17 AM
| | Banned
I am a: Type 2 | | Join Date: May 2007 Location: illinois
Posts: 3,316
| | | zocor reduces metabolic markers
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11-12-2007, 06:33 AM
| | Member
I am a: Type 1 | | Join Date: Oct 2007 Location: Scotland
Posts: 159
| | | So the "side-effects-free" drug, that according to many in the medical profession should be prescribed to ALL diabetics, regardless of their cholesterol numbers, causes reduced insulin-sensitivity.
Hey, that's just what we all need! |
11-12-2007, 07:37 AM
| | Banned
I am a: Type 2 | | Join Date: May 2007 Location: illinois
Posts: 3,316
| | | the new study contradicts the old study,which states that zocor reduces insulin sensitivity...now they say it's good for lowering insulin resistance.... |
11-12-2007, 09:48 AM
|  | Senior Member
I am a: Type 1 | | Join Date: Sep 2006 Location: Auckland, New Zealand
Posts: 2,095
| | The most interesting finding was this : Quote: |
Placebo was associated with a significant reduction (P<0.05) reduction in total cholesterol and LDL cholesterol, but did not significantly reduce plasma adiponectin levels or insulin sensitivity.
| If I understand this correctly, it means you can reduce your cholesterol if believe that what you are doing will have that effect. And there are no side effects with this mind-over-matter treatment! The mind boggles.
__________________
In my humble opinion  
Type1 since 1977
MDI using Lantus, Novorapid and Actrapid
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11-12-2007, 09:58 AM
| | Senior Member
I am a: Type 1 | | Join Date: Feb 2007
Posts: 1,583
| | | I would think they are talking about natural insulin produced by the pancreas...not injected? These reports are never clear on what exactly was studied. |
11-12-2007, 09:39 PM
| | Senior Member
I am a: Type 1 | | Join Date: Sep 2006 Location: Auckland, New Zealand
Posts: 2,095
| | | I think we must assume that the study was done on non-diabetics. So blood glucose would have been normal. They most probably measured insulin levels as a proxy for insulin resistance. The higher the insulin level, the greater the insulin resistance.
__________________
In my humble opinion
Type1 since 1977
MDI using Lantus, Novorapid and Actrapid
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11-16-2007, 03:45 PM
| | Junior Member
I am a: Type 1 | | Join Date: May 2006 Location: California
Posts: 14
| | | Am I reading it correctly that Zocor (simvastin) reduces insulin sensitivity? Isn't that the same as increasing insulin resistance?
I'm on simvastin and using CGMS (Dexcom), and it appears that my glucose levels go up about 40-50 points in the 1-2 hours after I take it (at bedtime). I was wondering if it was just my imagination, but it seems like this study could provide an expanation (lower insulin sensitivity --> higher blood glucose).
Has anyone else noticed this? |
11-16-2007, 04:32 PM
| | Member
I am a: Type 2 | | Join Date: Apr 2007 Location: Plano Illinois
Posts: 130
| | Quote:
Originally Posted by Type1er  Am I reading it correctly that Zocor (simvastin) reduces insulin sensitivity? Isn't that the same as increasing insulin resistance?
I'm on simvastin and using CGMS (Dexcom), and it appears that my glucose levels go up about 40-50 points in the 1-2 hours after I take it (at bedtime). I was wondering if it was just my imagination, but it seems like this study could provide an expanation (lower insulin sensitivity --> higher blood glucose).
Has anyone else noticed this? | That's how I read it too - my first thought was that it increased insulin resistance. I thought it was just me!
__________________
Diagnosed Type 2 February 14, 2007
A1C 2/07 11.8
A1C 4/07 7.4
A1C 9/07 6.5
A1C 2/08 6.4
Metformin 1000 mg x2
Lyrica 50 mg x 3
Simvastatin 20 mg x1
Hydrochlorothiazide 50 mg x 1
Methadone (for neuropathy) 2.5 mg x 1
Aspirin 81 mg x 1 |
11-16-2007, 04:39 PM
| | Senior Member
I am a: Type 1 | | Join Date: Jan 2007 Location: UK, Hampshire
Posts: 603
| | | this is a very strange article...
they are saying that zoccor reduces metabolic markers, which sounds like a good thing. Until you read that the markers are adiponectin levels and insulin sensitivity.
- adiponectin is a regulatory hormone produced by fat cells - adiponectin mobilises fat and decreases insulin resistance. Adiponectin appears to regulate body weight (more specifically fat mass)
let's make a prediction...
if we produce a drug that lowers adiponectin levels, a side effect should be weight gain. (as well as increased insulin resistance).
now go to google and type in statins and weight gain...
(I've already done it, and there are a lot of links with people on it complaining about weight gain) |
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