[ktk0117]

I've been on Glucovance for some time now, and the Docs feel I should stay on it. I eventaully need more and then another med added to the mix. Actos only made me fat and did little to reduce BS. Then Januvia, which at first worked ok, but now, I fight to stay in the low 200's.

So now they gave me Byetta and the first day it seemed to work, I was down to 150 for the first time in a long time.I was told to stop Januvia, and continue with Glucovance, But that first day of Byetta, I still had Glucovance & Januvia in my system.

Then daily my sugars rose back into the low 200's, and now a week later I'm into the high 200's to low 300's.

What gives, Byetta says it works with Metformin & Sulf. meds, which basically is what Glucovance is. So why the rise?

I'm thinking of going back on Januvia myself (still have a lot left) and backing off or quitting of Gluovance to see where Byetta/Januvia gets me.

But before I do, I wanted to know if anyone here has had trouble with Byetta & Glucovance together, and if so, what was done to remedy it?

Also, everyone says that Byetta will make me nausious & also curb my hunger, which in turn helps with carb intake when eating less. I have not experienced upset stomach or a loss of appetite even one time since 2 weeks of Byetta.

Makes me think Byetta is not even working at all for me.

My other problem is that when I get put on any new med, it works great for 6 months to a year, and then seems like it stops working. I asked the doc about building tolerance to meds, and he said he does not believe in that theory. But the more it happens to me, the I see the opposite.

Oh well, anyone been in my situation that might shed some useful info on this for me?

Thanks

[pdxdennisj]

You can override the benefits of any diabetes med with poor diet. I did it yesterday with Metformin, insulin and Byetta. I just ate lotsa carbs. My BG was 174 his morning (it usually is in the 90-110 range if I behave myself). Do you keep track of all the calories and carbs you eat? Thant is the only way I can stay in control.

[ktk0117]

Originally Posted by pdxdennisj

You can override the benefits of any diabetes med with poor diet. I did it yesterday with Metformin, insulin and Byetta. I just ate lotsa carbs. My BG was 174 his morning (it usually is in the 90-110 range if I behave myself). Do you keep track of all the calories and carbs you eat? Thant is the only way I can stay in control.

I've tried, I used to eat a salad for lunch and my BS would be like 90, now it will be around 190.

I also have eaten nothing more than a packet of Planters Peanuts and it used to be a good thing, I would be 80-90 after 2 hours, now 180+

[jerryn]

I was on Januvia, it messed my thyroid up and threw me into hyperthyroidism! My idle heart rate was like 99bpm. I got my
glucose down to 140 from 180 but the DR and I both new januvia was messing me up. So I went on Bayetta. If the Bayetta isn't working for you you need to be sure you are getting your full injection. I have had some pens fail and I didn't get a full dosage. I caught it, called the pharmacy and said look I'll bring the pen in and show you. It took a while but the mfr send me a certificate for a new pen. You really need to make sure your pen isn't jamming. I've found that if the bayetta pen is really cold this happens.

I take a Kaschi frozen dinner to work. This has helped me with my glucose level too. When I get home from work I'm usually around 130. You need to get some excercise too, there is no way around it. I'm an IT guy, sometimes people ask for help during lunch, now I say I will look at it when I get back from my walk. If they ask again I tell them again, after my walk, I need to watch my glucose.

When you get home, before or after supper go for another walk.

I have found if I do this my glucose levels stay within the normal range. If I just take my meds, have lunch from the work cafateria, and don't workout, heck my glucose will be 178 or so when I get home.

I know Metformin works great with Bayetta, maybe you need to ask about that. I take 1 500 in the morning and two 500 at night.

[ktk0117]

I am getting the full injection, and the inside plunger has certainly moved down. For the past 4 days I've increased from the 5mg to 10mg on my own, and it has no results. My sister uses Byetta with great success, me however, it's as though I'm taking nothing on top of Glucovance.

I'm on Glucovance which has Metformin in it, and I take 1000mg/twice a day of Metformin and 10mg/twice a day of Glyburide.in my 5/500 mg of Glucovance.

My last lab test showed I'm producing plenty of my own insulin too.

So, if others have been where I am, and diet and exercise seem as though they have little or no effect, then had going on insulin been the only way to go?

I ask because if I'm producing plenty of my own and my body ignores it, then what good would more do? Would it work because it is not my insulin and my body might respond to it then?

[jerryn]

If you are eating within the first 5 minutes then that could be why Bayetta has no effect. You need to wait 15 to 30 minutes. I notice best results after 30 minutes. You might want to ease into 30 minutes, start at 15, then 20, then 30.. because you may feel it. I do know that if I eat right after I take a bayetta shot it beter be an ultra low carb meal or I am going to be around 175 or so 2hrs after eat.

Good Luck!

[ktk0117]

Originally Posted by jerryn

If you are eating within the first 5 minutes then that could be why Bayetta has no effect. You need to wait 15 to 30 minutes. I notice best results after 30 minutes. You might want to ease into 30 minutes, start at 15, then 20, then 30.. because you may feel it. I do know that if I eat right after I take a bayetta shot it beter be an ultra low carb meal or I am going to be around 175 or so 2hrs after eat.

Good Luck!

.


I've tried that. Doc said eat anytime after injection. When that got me nowhere, I read the online instructions, and did the 30 minute thing, and both give me the same results, poor.

[jacobsam622]

Bayetta and Januvia are the same drug they were derived from lizards the only difference is that one is a pill the other(bayetta) is a shot. I have taken both Actos and Januvia at different times. The Doctor took me off Januvia but I put myself back on it because I am tired of throwing money away on drugs that I pay for and never finish. Actos works great but it takes about six weeks before you see any real progress.
Actos avantia and Metformin are sensitizers. **Can cause Heart failure**

Glucovance, glipazide, amaryl all help your body make more insulin.

Bayetta and Januvia are DPP-4 inhibitors help your body make more insulin and they are suppose to tell your liver to stop producing glucose I have not seen any improvement yet.

My point is taking both Bayetta and Januvia would be the same as increasing the amount of medicine. Try taking one of them with a sensitizer and give it at least six weeks.

[ktk0117]

Originally Posted by jacobsam622

Bayetta and Januvia are the same drug they were derived from lizards the only difference is that one is a pill the other(bayetta) is a shot. I have taken both Actos and Januvia at different times. The Doctor took me off Januvia but I put myself back on it because I am tired of throwing money away on drugs that I pay for and never finish. Actos works great but it takes about six weeks before you see any real progress.
Actos avantia and Metformin are sensitizers. **Can cause Heart failure**

Glucovance, glipazide, amaryl all help your body make more insulin.

Bayetta and Januvia are DPP-4 inhibitors help your body make more insulin and they are suppose to tell your liver to stop producing glucose I have not seen any improvement yet.

My point is taking both Bayetta and Januvia would be the same as increasing the amount of medicine. Try taking one of them with a sensitizer and give it at least six weeks.

HHMMM, I'm not quite sure you have your facts straight. Byetta & Januvia work in very different ways:

How BYETTA (exenatide) injection Works for Type 2 Diabetes

And

JANUVIA™ (sitagliptin) tablets: Learn more at Januvia.com

[jacobsam622]

Originally Posted by ktk0117

HHMMM, I'm not quite sure you have your facts straight. Byetta & Januvia work in very different ways:

How BYETTA (exenatide) injection Works for Type 2 Diabetes

And

JANUVIA™ (sitagliptin) tablets: Learn more at Januvia.com

Januvia is known as a DPP-4 inhibitor. DDP-4 inhibitors are part of a
broader class of medicines known as incretin mimetics, such as
Byetta (exenatide). However, unlike Byetta (which must be injected
twice per day) Januvia is a pill. [source]

[ktk0117]

Originally Posted by jacobsam622

Januvia is known as a DPP-4 inhibitor. DDP-4 inhibitors are part of a
broader class of medicines known as incretin mimetics, such as
Byetta (exenatide). However, unlike Byetta (which must be injected
twice per day) Januvia is a pill. [source]

I looked all over the Byetta site, and do not see DDP-4 inhibitor, can you link to what you reference?

[jacobsam622]

Are they exactly same no but both tell the pancreas to create more insulin, and both tell the liver to stop producing glucose. They are both from the same new class of diabetes medicine. The Pharmaceutical Company that I work for has several in development.

[ktk0117]

Originally Posted by jacobsam622

Are they exactly same no but both tell the pancreas to create more insulin, and both tell the liver to stop producing glucose. They are both from the same new class of diabetes medicine. The Pharmaceutical Company that I work for has several in development.

Gotcha, now I understand.

Funny thing is, Januvia loweded my BS about 30-60 points. Not enough for my Doctor to be happy with, so he put me on Byetta.

Byetta did not work at all. It was as if I stopped taking Januvia all together and added nothing else. My BS rose 50-100 points and maxed out over 340 at times. He quickly got me off of Byetta, and now I'm on Anvandia/Glucovance combo for about a week now, and I'm down from upper 200's lower 300's to averaging 180. Still not where I need to be, but better than Byetta.

But now I ask, if Januvia and Byetta pretty much do the same thing, why does one work, and not the other?

Strange.

[jacobsam622]

Originally Posted by ktk0117

Gotcha, now I understand.

Funny thing is, Januvia loweded my BS about 30-60 points. Not enough for my Doctor to be happy with, so he put me on Byetta.

Byetta did not work at all. It was as if I stopped taking Januvia all together and added nothing else. My BS rose 50-100 points and maxed out over 340 at times. He quickly got me off of Byetta, and now I'm on Anvandia/Glucovance combo for about a week now, and I'm down from upper 200's lower 300's to averaging 180. Still not where I need to be, but better than Byetta.

But now I ask, if Januvia and Byetta pretty much do the same thing, why does one work, and not the other?

Strange.

Good question, I think a lot of these new drugs are being pushed through before they have been tested on large enough groups to determine how effective they really are. the new incretin mimetics work for some people and not for others. My guess is that slowing down the stomach causes blood sugar to react differently from person to person. I have been on Januvia for about six months now I think its just starting to work for me.