Antibiotics and Blood Glucose Levels
Posted 05 March 2007 - 04:04 PM
T2, diagnosed 8/31/06.
Meds: Metformin-ER 500 mg twice daily, HCTZ 12.5 mg every other day for BP Enalapril 20 mg 1 daily (ace-inhibitor)
Diet: I eat to my meter, generally eating 75-100 carbs/day with the occasional splurge.
Posted 05 March 2007 - 04:06 PM
March a1c 6.4
Pumper 522 with Humalog
Posted 05 March 2007 - 06:15 PM
I just mentioned this in princesslinda's post. A few weeks ago, I had an upper respiratory inflection. I didn't see any effect on my blood sugar. I went to the doctor. He gave me a z-pak. You take two pills the first day. Shortly, after taking the first two pills, my blood sugar went over 200 and stayed there for about twenty-four hours. For the four days when I was on one pill; it was a little high. Did the antibiotics cause my high blood sugar? I don't know. But I do know that my blood sugar didn't go up when I got sick; it went up when I took the medicine.
P.S. If you have strep, you really need to treat it aggressively. My late mother got rheumatic fever from untreated strep; you don't want to get that.
Posted 05 March 2007 - 06:43 PM
"This one makes a net. This one sits and wishes. Can you make a bet, which one catches fishes?"
Syd--20 years Type II diabetes 18 years insulin dependent.
Posted 05 March 2007 - 07:59 PM
At first I though I was having set or absorption problems. I ended up taking a correction bolus this morning from a syringe after 2 from the pump failed to help; and my bg continued to rise even though I hadn't eaten anything.
For the last few days, I have fought high bg pushing large amounts of insulin to keep the bg from going completely out of control. And then later in the day or at night, I end up going low, long after the duration of the last bolus should have had any effect. It's almost like the antibiotic or something else is causing the insulin to have a delayed action.
I have not eaten since lunch, around 11:30. I've been fighting going low since about 3:30. I just checked in at 69 and decided to delay dinner for an hour since I took another antibiotic pill. I want to see if the pill alone is raising my bg. It's extremely frustrating to not know what is causing this...
Posted 05 March 2007 - 08:23 PM
Hope you feel better soon.
Mom always says I'm special. Hmmm........wonder what she means by that?? LOL.
The best and most beautiful things in the world cannot be seen or touched, they must be felt with the heart.
Posted 05 March 2007 - 09:41 PM
The cephalexin suspensions contain sucrose. Individuals with diabetes may need to be aware of the sucrose contained in these suspensions.
I'm taking capsules, so I'm not sure if this one applies.
We investigated whether cephalexin transport in Caco-2 cells is regulated by insulin. After the insulin pretreatment, cephalexin uptake, and transport as well as PEPT1 mRNA and protein expression in the cells were measured. Cephalexin uptake was significantly increased by the insulin pretreatment. Insulin significantly increased cephalexin saturable uptake, but had no significant effect on the non-saturable one. PEPT1 protein expression on the apical membrane, but not PEPT1 mRNA expression, was increased by the insulin pretreatment. The enhancement of cephalexin uptake by the insulin pretreatment was inhibited by genistein, a tyrosine kinase inhibitor, and colchicine, an agent that disrupts protein translocation. Apical-to-basolateral transport of cephalexin has increased by the insulin pretreatment at the apical side and long-term insulin pretreatment at the basolateral side. It is considered that insulin mainly binds to its receptor on the apical and basolateral membranes, thereby promoting PEPT1 translocation from the intracellular pool to the apical membrane surface; consequently, PEPT1 protein expression on the apical membrane is increased.
This one I really don't understand very well, but it seems there is a reaction between insulin and the medication.
Posted 06 March 2007 - 08:39 AM
I'm almost afraid to take my meds this morning. I woke to an 84, but went up to 150 after riding the stationary bike for a bit. Guess I'd better fill my reservoir now!
Hey this is exactly what happens to me, a rise, first you are a1 lucky you have a pump, I am on mdi, I go up on my latus my 2 units when I am sick number one, so maybe a sick basal should be figured by all this for you.....I also have a tendency to drop a bit too, it's kind of like when the infection is getting a run for it's money my body likes it and I get low....it's not fun, and also another person I know was sick and was trying to keep active to keep bg's on track oh god no it made his bg's worse, I'd say rest up the basal's and don't worry too much if you go in the mid 100's a lot of people go really high and that is not bad for an infection, Seriously....I hope you get better
March a1c 6.4
Pumper 522 with Humalog
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