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whats the most metformin you can take?

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#1
baltbob

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Been type 2 for about a year now. First a1c results were ove 11 and now down around 6.1. Last six months I was having morning fasting numbers between 100-125. However the last month my fasting numbers in the morning are averaging around 150.. There has been no major changes in my diet or excercise progam. I take metformin (1000) twice a day. Exercise regulary and am not overweight. Do you think it may be time to go with more metformin? I see my MD again next month. What is the highest amount of metformin you can take?

#2
princesslinda

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I did a search, and on medicinenet.com as well as some others, the maximum dosage for metformin is 2550 mg/day, generally divided into 3 doses. I don't think i've ever typed any dication on anyone taking over 1000 mg twice a day (at least in the 3 years i've been on it...probably didn't pay attention before then).

Have you experimented with taking your dinner dose at bedtime to see if it will help the a.m. numbers? I take my metformin around 10 pm....just not on an empty stomach.

T2, diagnosed 8/31/06.
Meds: Metformin-ER 500 mg twice daily, HCTZ 12.5 mg every other day for BP Enalapril 20 mg 1 daily (ace-inhibitor)
Diet: I eat to my meter, generally eating 75-100 carbs/day with the occasional splurge.


#3
Masher

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I take 3 mets a day breakfast lunch Dinner. for a total of 1500

I tried moving my dinner metformin to when i go to bed seemed to help me this morning. might have been a fluke

#4
Lloyd

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I've been on 850 3x for almost 15 years.

That's the max dosage.

-Lloyd

2014 A1c 5.4 5.6 5.8 5.6   2013 5.3 4.9 5.2 5.2

2012 5.3 5.2 5.1 5.0 2011 5.0 5.0 5.2 5.0 2010 5.3 5.3 5.3 5.4 5.4

2009 5.4 5.4 5.3 5.2 2008 5.0 5.1 5.2 4.9 4.9

2007 5.3 5.5 5.7<---Pump 6.9 (Mix)

2006 (Lantus) 7.8 8.5 8.7 7.1

2005 8.4 6.9 7.4 2004 6.2 5.6 6.4 6.0 (Pills)


#5
ticktwrter

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I take 1000 met in the morning and 1500 with dinner in the evening

#6
BigcityRich

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I took 850MG 3 x day for a year before I switched to ER version. I was told ER version is only 750MG. I have taken 750mg 3 x day for over a year.
Richard

Type 2 since 2/07
Metformin ER 750mg 3x daily
Glipizide 5mg 2x daily

HbA1c
2/07 - 10.3%
6/07 - 6.0%
2/08 - 6.2%
7/08 - 6.0%
2/09 - 5.9%

#7
alicat61

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:) Hi,
I take 1000mg 3 times a day and have done so for about 15 years with no problems.




Take care from Alicat61:)

On 5th May 2010 had a Lap Band fitted
Has changed my life
Humalog only if needed. (BGL above 6mmols)
Lantus daily
Metformin 1gm 3x a day
Propranalol 40 mgs 2 x a day

#8
davef

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Have you experimented with taking your dinner dose at bedtime to see if it will help the a.m. numbers? I take my metformin around 10 pm....just not on an empty stomach.


I'm on 500mg twice a day and when I did the same as Linda, it really did make a difference to my morning numbers.

0F869DE117BBAE6820F3DD49C762BF1A.png

By Endurance, we conquer - Shackleton Family Motto
Insulin resistance is futile - I will win - me

Metformin 3000mg daily, Enap 5mg, Victoza 1.8mg, Lantus (currently 50u)
Diagnosed T2 on 26th Nov'07, with FBG of 21mmol/L (378mg/dL) and A1c of 11.6%.

 

A1c

Most recent 08/09/14: 8.2% (down 3.4%)

20/11/13: 11.6%


#9
xMenace

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There's no real limit per se. The problem is any more than 2000 to 2500 mg will have no additional affect. That much saturates your system, but you need to have insulin for it to help.

When this max doesn't work, it's time for other meds to boost insulin production or insulin injections.

Virginia Woolf: “Consider how common illness is, how tremendous the spiritual change that it brings, how astonishing, when the lights of health go down, the undiscovered countries that are then disclosed, what wastes and deserts of the soul a slight attack of influenza brings to view, what precipices and lawns sprinkled with bright flowers a little rise of temperature reveals, what ancient and obdurate oaks are uprooted in us by the act of sickness, how we go down in the pit of death and feel the waters of annihilation close above our heads and wake thinking to find ourselves in the presence of the angels and the harpers when we have a tooth out and come to the surface in the dentist's arm-chair and confuse his "Rinse the mouth-rinse the mouth" with the greeting of the Deity stooping from the floor of Heaven to welcome us - when we think of this, as we are so frequently forced to think of it, it becomes strange indeed that illness has not taken its place with love and battle and jealousy among the prime themes of literature”
Back on MDI and doing well. Trying Victoza and loving it. A1C 6.0, no major hypos; a few highs; lots of shots. Diagnosed Oct 19th, 1975.
HDL-101; LDL-64; TG-36; TOT-172


#10
Hammer

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You didn't mention what your after meal numbers were. Have they remained the same or have they jumped up also? If your numbers are higher in the morning and after eating, then you probably need to change your medications....either add more metformin or add another med.
Myself, I prefer using insulin as it has a much better lowering effect on my numbers, plus the only side effect is weight gain.(sometimes). I also take Byetta which can make you lose weight. For me, my doctor told me I was taking the Byetta at the wrong times.....I took it 30-60 minutes before I ate. He told me I should take it immediately before I ate as it only stays in your system for a short time.(the instructions tell you to take it 30-60 minutes before you eat.) I changed to taking it immediately before eating and I'm losing weight. My numbers seem to be okay taking it that way.
Anyway, good luck on getting your numbers down and keep us posted.

Presently taking: Hyzaar for blood pressure:
Novolog and Lantus for diabetes.
Welchol for cholesterol and diabetes
Mega-Red Omega-3 Krill Oil (300 mg)
Mega-Red D3 (5000 IU)
I was diagnosed in 2003...

(The human body is so resilient that no matter how badly you abuse it, it will still last you a lifetime.)


#11
baltbob

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thanks for all the info. Last night was a perfect example.Took a walk before dinner and was a hundred one hour after I ate . Later I had a apple around nine oclock. I was 163 when I went to bed about ten. Woke up at 164. I am going to start taking evening dose right before I go to bed and see if it helps any till I see the doc in six weeks and see what my new a1c score is. Hope it has not gone up too much.Thanks

#12
huskerdaughter

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According to my DR. 2000mgs daily is the max. and thats what im on. Just becareful. That much makes me very very sick so i take it just before bed and sleep off the upset tummy and all that goes with it.
"The sword of Damocles is hanging over my head and i have the feeling that someones gonna be cutting the thread"


Lantus Pen 30-40 units daily
humalog kwikpen sliding scale 0-30 units 0-4 times daily
Metforminn - 1000 morning, 1000 nightly
Vit-D 8000 mg daily
Tramadol 100mg daily
folic acid 800 mg daily
Cinnamon 1000 morn 1000 night
12-19-08 A1c 13.1
03-09-09 A1c 11.0

12-19-08 starting sugars 394
12-20-08 down to 313
12-23-08 down to 183
01-09-09 down to 120

#13
art

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My Doc also told me 2000 per day is max and that's where I'm at.

Art

#14
Holly

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At my diabetic education class, the nurse gave the figure of 2000 daily as the max. I guess that is the Ontario standard.

#15
Lloyd

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There is no fixed dosage regimen for the management of hyperglycemia in patients with type 2 diabetes with GLUCOPHAGE or GLUCOPHAGE XR or any other pharmacologic agent. Dosage of GLUCOPHAGE or GLUCOPHAGE XR must be individualized on the basis of both effectiveness and tolerance, while not exceeding the maximum recommended daily doses. The maximum recommended daily dose of GLUCOPHAGE is 2550 mg in adults and 2000 mg in pediatric patients (10-16 years of age); the maximum recommended daily dose of GLUCOPHAGE XR in adults is 2000 mg.

Glucophage, Glucophage XR (Metformin Hcl) Drug Information: Uses, Side Effects, Drug Interactions and Warnings at RxList

-Lloyd

2014 A1c 5.4 5.6 5.8 5.6   2013 5.3 4.9 5.2 5.2

2012 5.3 5.2 5.1 5.0 2011 5.0 5.0 5.2 5.0 2010 5.3 5.3 5.3 5.4 5.4

2009 5.4 5.4 5.3 5.2 2008 5.0 5.1 5.2 4.9 4.9

2007 5.3 5.5 5.7<---Pump 6.9 (Mix)

2006 (Lantus) 7.8 8.5 8.7 7.1

2005 8.4 6.9 7.4 2004 6.2 5.6 6.4 6.0 (Pills)


#16
Gabby123

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My Doc also said max 2000 mg per day

#17
groovydb

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I am supposed to up my met dosage to 1500 from 1000 today.. but I cant stand the thought of more tummy troubles! I take 500mg in the morning and 500mg before bed. From what I am reading, if I take 500 in the morning and 1000 at bedtime, I could possibly sleep away my stomach issues? I just had terrible nausea and a bloated feeling when I went from 500mg to 1000mg per day.

#18
xenablue

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My Doc says 2500mg is the max dose - after that it's ineffective.

I'm on the 2500mg/day and a few days ago started taking the entire 2500mg at night to see if it helped my 'during the night' and FBG. DH is waking me at 2:30am to test so will look at the numbers after a week and see if it makes any difference.

#19
NickP

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I have read that 2500mg is the max doseage for Metformin. 2000mg is the max doseage for Metformin XR.
Nick
Feb 17, 2010 - Initial A1C 9.3 Weight 238
May 26, 2010 - A1C 6.0
Aug 20, 2010 - A1C 5.6
Nov 19, 2010 - A1C 5.8
Mar 1, 2011- A1C 5.7 (No Meds)
Jun 3, 2011 - A1C 5.7 (No Meds)
Oct 31, 2011 - A1C 5.3
Nov 6, 2012 - A1C 5.3
Feb 18, 2014- A1C 5.6 Weight 199

Current Meds:
Metformin 500mg x 2

#20
foxl

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I have read that 2500mg is the max doseage for Metformin. 2000mg is the max doseage for Metformin XR.


Yep that is it as far as I have read, too.
Linda


[B]Jan A1c 6.3/B]
Jul 09 ... C-pep 1.3, GAD-65 > 30
Mar 10 C-pep 2.8 (20 g carb); GAD 3.2
dx 02/09 in DKA


Levemir 12U per day; novolog PRN TDD ca 16U
MetforminXR 1000 mg BID
Ramipril 5 mg
T4 112 mcg
Chia oil
Vitamin D3, 4000 IU
Eating 20 - 45 g carb per day ovo-lacto-vegetarian
Walking 30 min 6x week




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