Jump to content

Photo

Metformin and Weight Loss

- - - - - weight loss type 2

  • Please log in to reply
51 replies to this topic

#1
deercotn

deercotn

    Member

  • 500 plus
  • 289 posts
Has anyone else experienced weight loss while on metformin? I'm taking 500 mg 3x daily (with each meal).

I'm exercising but I suspect the weight loss may be largely due to metformin. Anyone else had this happen?

Why/how does metformin cause weight loss? NO CHEMISTRY LESSONS PLEASE-- just plain language explanations. Thanks.
Diagnosed 09/2003
BG at diag 324
A1c at diag 9.7
Lowest A1c 6.0 (08/09)
Most Recent A1c 6.4 (06/10)
Glyburide-Metformin 2.5-500mg 3x daily
Enalapril
Norvasc
Crestor
Fish Oil 1000 mg 2x daily
Levitra ....
:D
Brisk walk 30 min 5x weekly

[SIGPIC][/SIGPIC]

#2
princesslinda

princesslinda

    Super Moderator

  • Moderators
  • 16,009 posts
  • LocationKnoxville, TN
  • I am a:Type 2
It is my understanding that metformin works by helping your body better use the insulin you're producing. Insulin resistance can contribute to weight gain, esp. around the midsection, so by minimizing insulin resistance (by exercise and metformin) you may lose weight.

I lost weight when first diagnosed, due in part to significant lifestyle changes and metformin. I take 500 mg twice a day, and I don't see the weight loss anymore, probably because I am not as physically active as I was then.

Glyburide, on the other hand, can cause weight gain. I'm betting that its all the lifestyle changes you made that have made the most difference.
  • stinastina and golavi like this

T2, diagnosed 8/31/06.
Meds: Metformin-ER 500 mg twice daily, HCTZ 12.5 mg every other day for BP Enalapril 20 mg 1 daily (ace-inhibitor)
Diet: I eat to my meter, generally eating 75-100 carbs/day with the occasional splurge.


#3
buddy7

buddy7

    Senior Member

  • 500 plus
  • 2,534 posts
I'd say definitely yes to that, noted in my first year taking Metformin.
  • Cindy Denning likes this
DX 8/2004
Current Meds
Metformin X2 500 mg
Ramipril 10mg
Amlodipine 5mg
Aspirin 75mg
Simvastatin 20mg
2005/6 Getting my
Head around this
Condition.
07- HbA1C 5.2 ChoL 3.2 // 08- HbA1C 5.4 Chol 4.2 // 09- HbA1C 5.5 Chol 3.6 LDL 1.9 HDL 2.5 Trig 0.60
10- HbA1C 5.5 Chol 3.7 LDL 1.8 HDL 1.53 Trig 0.82 // 11- HbA1C 5.7 Chol 3.9 LDL 2.0 HDL 1.5 Trig 0.75 //12-HbA1C 5.9 Chol 4.4 LDL 2.2 HDL 1.98 Trig 0.58 // Sep12-HbA1C 5.8 Chol 4.5 Trig 0.48 LDL 2.1 HDL 2.2

Buddy 7 Essex uk

#4
deercotn

deercotn

    Member

  • 500 plus
  • 289 posts
I've dropped 20 lbs in 3-4 months. Frankly, I'm shocked at how easily it has come off. The only "lifestyle" changes I've made are:
- taking my meds like I'm suppose to (3x rather than 1 or 0)
- walk/jog 2 miles 5-6 times a week
- low carb breakfast and eliminate/reduce snacks (this probably cuts a total of 50-80 carbs a day)

This just doesn't seem like it would be sufficient to drop 10% of my body weight so quickly when so many folks struggle to lose weight. That's why I was thinking maybe the metformin was the leading contributor.
Diagnosed 09/2003
BG at diag 324
A1c at diag 9.7
Lowest A1c 6.0 (08/09)
Most Recent A1c 6.4 (06/10)
Glyburide-Metformin 2.5-500mg 3x daily
Enalapril
Norvasc
Crestor
Fish Oil 1000 mg 2x daily
Levitra ....
:D
Brisk walk 30 min 5x weekly

[SIGPIC][/SIGPIC]

#5
deercotn

deercotn

    Member

  • 500 plus
  • 289 posts

I'd say definitely yes to that, noted in my first year taking Metformin.


"yes" to what? Metformin causing my loss?
Diagnosed 09/2003
BG at diag 324
A1c at diag 9.7
Lowest A1c 6.0 (08/09)
Most Recent A1c 6.4 (06/10)
Glyburide-Metformin 2.5-500mg 3x daily
Enalapril
Norvasc
Crestor
Fish Oil 1000 mg 2x daily
Levitra ....
:D
Brisk walk 30 min 5x weekly

[SIGPIC][/SIGPIC]

#6
sanflan

sanflan

    Member

  • 500 plus
  • 291 posts

"yes" to what? Metformin causing my loss?


This didn't happen to me, but my husband is thinner than he has ever been. He has lost so much weight on Metformin and he has had a severe weight problem, since he was in his teens. He just isn't hungry anymore. He looks great and is starting to give me a hard time about my weight.
  • stinastina likes this

#7
mosaic

mosaic

    Junior Member

  • 500 plus
  • PipPipPip
  • 49 posts
Hard to tell for me, since I cut out most sweets, sugary sodas, sandwiches, etc. when I was diagnosed -- and that was when I also started metformin -- but I dropped 15 lbs in about 2 months. Another 10 since.
  • stinastina and tOmMy like this
Diagnosed Type 2 - 1/27/2009
Foot problems due to Charcot arthropathy
02/10/2010 a1c: 6.1
11/07/2009 a1c: 5.8
08/13/2009 a1c: 6.2
05/12/2009 a1c: 7.1
01/27/2009 a1c: 10.3
Janumet 50/1000mg 2x daily
Using WaveSense Jazz meter

#8
howkasam

howkasam

    Junior Member

  • 500 plus
  • PipPip
  • 16 posts
I read that people, who use metformin, as I do, tend to lose weight. The person who wrote the article said that it is probably because merformin irritates the stomach. I have not lost weight and my stomach is not irritated. I guess people are different.

#9
foxl

foxl

    Senior Member

  • 500 plus
  • 13,756 posts

I read that people, who use metformin, as I do, tend to lose weight. The person who wrote the article said that it is probably because merformin irritates the stomach. I have not lost weight and my stomach is not irritated. I guess people are different.


I have read it is just decreased appetite. I know I have had no discomfort from its use and have less appetite, myself. Now if I can get off this lipogenic Actos ...
Linda


[B]Jan A1c 6.3/B]
Jul 09 ... C-pep 1.3, GAD-65 > 30
Mar 10 C-pep 2.8 (20 g carb); GAD 3.2
dx 02/09 in DKA


Levemir 12U per day; novolog PRN TDD ca 16U
MetforminXR 1000 mg BID
Ramipril 5 mg
T4 112 mcg
Chia oil
Vitamin D3, 4000 IU
Eating 20 - 45 g carb per day ovo-lacto-vegetarian
Walking 30 min 6x week

#10
slipperyelm

slipperyelm

    Senior Member

  • 500 plus
  • 1,465 posts
Generally, the more overweight you are to begin with, the easier it comes off.

I would guess that you have decreased you calorie intake during the time that you lost weight. The amount of weight loss attributable to metformin is fairly small, if I recall correctly. Something like 4 pounds average. I think the info is on the pharmaceutical data sheets for metformin at your manufacturer's website.

If you are wondering whether the extra doses you have taken ( I think that was you?) are interfering with your health, really, I think it would be good to chat with your pharmacist (especially if no one here is able to give you the sort of info you are looking for).

#11
Subby

Subby

    Senior Member

  • 500 plus
  • 10,158 posts
Also not mentioned here is that metformin suppresses gluconeogenesis, and the resultant insulin reduction benefits.

NO CHEMISTRY LESSONS PLEASE-- just plain language explanations. Thanks.


OK, heres a translation, but it can't be completely dumbed down. Metformin reduces or dampens the amount of glucose or energy your body generates internally (this goes on all the time as part of the body functioning). This means less insulin is required for the body to function without high blood sugars. So, your body releases less insulin.

In the absence of constant activity to burn up the energy, less glucose in the blood stream and less insulin, may equal less storage of the glucose as fat.
20 years T1. NPH and Novorapid.
Some essentials for my blood sugar control: dosing via i:c ratio and cf • basal testing when needed • daily 40 minutes moderate exercise (or close) • carbs somewhere below 120g currently • only eating carbs and carb/fat combos that do not cause a problem spike, with or without insulin.

#12
foxl

foxl

    Senior Member

  • 500 plus
  • 13,756 posts

Also not mentioned here is that metformin suppresses gluconeogenesis, and the resultant insulin reduction benefits.



OK, heres a translation, but it can't be completely dumbed down. Metformin reduces or dampens the amount of glucose or energy your body generates internally (this goes on all the time as part of the body functioning). This means less insulin is required for the body to function without high blood sugars. So, your body releases less insulin.

In the absence of constant activity to burn up the energy, less glucose in the blood stream and less insulin, may equal less storage of the glucose as fat.


You'd be a good jr. hi science teacher! :T
Linda


[B]Jan A1c 6.3/B]
Jul 09 ... C-pep 1.3, GAD-65 > 30
Mar 10 C-pep 2.8 (20 g carb); GAD 3.2
dx 02/09 in DKA


Levemir 12U per day; novolog PRN TDD ca 16U
MetforminXR 1000 mg BID
Ramipril 5 mg
T4 112 mcg
Chia oil
Vitamin D3, 4000 IU
Eating 20 - 45 g carb per day ovo-lacto-vegetarian
Walking 30 min 6x week

#13
Gozelle

Gozelle

    Member

  • 500 plus
  • 149 posts
I think it is the exercise and not the meds. I was put on Metforun 500 2X in January and did not one thing differently. Then in June, I got real and eat very right because I test all the time and am learning a lot. Have also started walking 2 miles most days. I have lost 20 pounds . . . I lost nothing on meds alone.
Lady Baby Boomer

6/09 A1c 6.1
9/09 A1c 5.7
6/10 A1c 5.9
Metformin 2 x 1000 and meds for BP

#14
Subby

Subby

    Senior Member

  • 500 plus
  • 10,158 posts

You'd be a good jr. hi science teacher! :T


That's pretty funny, I actually failed year 10 general science. :D

(So don't listen to a thing I say without double checking it... probably like you should with every jr hi science teacher!)

20 years T1. NPH and Novorapid.
Some essentials for my blood sugar control: dosing via i:c ratio and cf • basal testing when needed • daily 40 minutes moderate exercise (or close) • carbs somewhere below 120g currently • only eating carbs and carb/fat combos that do not cause a problem spike, with or without insulin.

#15
foxl

foxl

    Senior Member

  • 500 plus
  • 13,756 posts

That's pretty funny, I actually failed year 10 general science. :D

(So don't listen to a thing I say without double checking it... probably like you should with every jr hi science teacher!)


Ask me about chemistry grades ... :eek: They actually were the one thing that kept me out of medical school, for which right now I am grateful!
Linda


[B]Jan A1c 6.3/B]
Jul 09 ... C-pep 1.3, GAD-65 > 30
Mar 10 C-pep 2.8 (20 g carb); GAD 3.2
dx 02/09 in DKA


Levemir 12U per day; novolog PRN TDD ca 16U
MetforminXR 1000 mg BID
Ramipril 5 mg
T4 112 mcg
Chia oil
Vitamin D3, 4000 IU
Eating 20 - 45 g carb per day ovo-lacto-vegetarian
Walking 30 min 6x week

#16
leolion50

leolion50

    Junior Member

  • Members
  • Pip
  • 4 posts
Hello!! to everyone, I'm new to this forum and being a diabetic. I'm a diabetic 2 and on metformin 500mg 2x a day, being on this medication and walking 5 days out of the week I too have lost five pounds in a months time my doctors said that was good but I want to loss 15 to 20 pounds in a months time.
:) Lola

#17
gocubsgo

gocubsgo

    Junior Member

  • 500 plus
  • PipPip
  • 24 posts
I don't think it necessarily makes you lose weight, but my doctor told me that Metformin is one of the only diabetes medications that doesn't cause weight gain. So maybe it's more lifestyle changes partnered with the fact that it doesn't cause weight gain unlike others such as Gluberide.

I was on Metformin for about a year (my doctor just switched me over to Actoplus Met) and it wasn't until I actually made lifestyle changes that I saw a change on the scale. But it's true for some that Metformin causes appetite loss and upset stomach (I'd randomly lose my appetite for about a week every few months).
  • stinastina likes this

#18
leolion50

leolion50

    Junior Member

  • Members
  • Pip
  • 4 posts
Hello!!!Room!!! I wanted to introduct myself to this forum, my name is Lola and I need :eek: help anyway that I can get it with being a type 2 diabetic and on metformin 500mg 2x a day.
:) Lola

#19
luckharm

luckharm

    Junior Member

  • 500 plus
  • PipPip
  • 28 posts
I lost 30 lbs in 1 year on Metformin. I am 5'4" and went from 150lbs to 120lbs which is my ideal weight. I truly believe that the Metformin contributed to my weight loss as well as my diet and exercise change. I just hope now, I don't lose anymore.


Margie
Type 1.5
Diagnosed 6/08
A1C - 10.7 on 6/08
A1C - 8.9 on 8/09
A1C - 7.2 on 11/10
A1C - 6.7 on 12/11
A1C - 7.2 on 11/12

A1C - 7.1 on 3/13

A1C - 7.1 on 4/14
Lantus -15 units per day
Humalog - 14 units per day


#20
Granny Shanny

Granny Shanny

    Banned

  • Banned
  • 3,380 posts
I've lost 15 lbs. in 10 weeks with very little exercise, and a low-carb high-fat diet. It about has to be the metformin in my case. I think it helps suppress appetite, but I don't have a clue what the physiological effects might be.




0 user(s) are reading this topic

0 members, 0 guests, 0 anonymous users