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Why does Lantus sting only sometimes?

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#1
wiseguy

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I do every injection exactly the same way, always warming up the Lantus first. So why does the Lantus sting in about one out of three injections and not every time?

#2
fgummett

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http://www.diabetesf...difference.html

#3
wiseguy

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Great article but it doesn't explain why Lantus stings only sometimes. Also, should I derive from this that Levemir does not sting at all?

#4
jtausch

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I use levemir and it does not sting. I read somewhere that it is the PH of the lantus causes it to sting when injected. I is a different PH than you body so it can sting when you use it. Don't remeber tho where i read it.
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#5
Bountyman

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Since Lantus needs a pH level of 4 in order to maintain a liquid state it's acidic in nature and will remain so until the fluids around your injection site neutralize it. Once the pH of Lantus reaches your body's pH level of 7.0 it crystalizes and starts releasing insulin.

Being a "subcutaneous" injection the Lantus is neutralized by the fat cells. The more fat cells around the injection site the quicker the Lantus neutralizes. Were you to use a needle that injected the Lantus deep into a fat area you'd never feel the acidic burn; fat cells have no pain receptors in them.

#6
wiseguy

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Since Lantus needs a pH level of 4 in order to maintain a liquid state it's acidic in nature and will remain so until the fluids around your injection site neutralize it. Once the pH of Lantus reaches your body's pH level of 7.0 it crystalizes and starts releasing insulin.

Being a "subcutaneous" injection the Lantus is neutralized by the fat cells. The more fat cells around the injection site the quicker the Lantus neutralizes. Were you to use a needle that injected the Lantus deep into a fat area you'd never feel the acidic burn; fat cells have no pain receptors in them.

So this is could make a case for using longer needles.

#7
janice21475

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This could account for the sting my husband is getting lately. He switched from 8mm length to 5mm length. It is considerable shorter. Looks more like a Rose thorn. :eek:

Never have to prime it, plug the thing in and it immediately forms a droplet.

The sting is not awful but at times a wake you up thing.

Interesting thread and that article, especially.

Thanks for the explanations,
Janice & Husband

#8
NewdestinyX

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So this is could make a case for using longer needles.

Yes exactly. You can get longer needles. I use the 8mm and get a sting once every 20th injection or so. Not one in three for me. I always use the sides of my belly which still have 'plenty' of fat. And I press in the needle pretty good.

You implied you 'warm up' the Lantus each time. Are you putting the pen back in the frig every day? You shouldn't be. Leave it room temperature from the day you start a new pen. It will last for up to 35-40 days. Cold Lantus will always sting more. You're only supposed to be leaving un-started pens in the frig.
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#9
wiseguy

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Yes exactly. You can get longer needles. I use the 8mm and get a sting once every 20th injection or so. Not one in three for me. I always use the sides of my belly which still have 'plenty' of fat. And I press in the needle pretty good.

You implied you 'warm up' the Lantus each time. Are you putting the pen back in the frig every day? You shouldn't be. Leave it room temperature from the day you start a new pen. It will last for up to 35-40 days. Cold Lantus will always sting more. You're only supposed to be leaving un-started pens in the frig.

I don't use a pen. I use syringes with the 8mm needles. The Lantus is left out at room temperature, but after I fill the syringe, I warm it a little more by rolling it between my hands for a few seconds.

#10
Bountyman

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I don't use a pen. I use syringes with the 8mm needles.


If you're feeling the sting a little too often, try a more acute angle with the needle. The more the angle towards vertical, the deeper the injection.

#11
Subby

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It will last for up to 35-40 days.


What is your source for this? The Lantus website gives the indication that a vial or pen should be discarded at 28 days.
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