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Should I take metformin?

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#1
GeorgeOttawa

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My most recent FBG is 117, and HBA1C is 5.3%. These numbers have been with me for past 2.5 years. My doctor now asks me to take 500mg Metformin, twice a day. I don't like to take any medication. In your opinion, should I take Metformin? I learned there is a Metformin extended release (ER) version, is Metformin ER better than Metformin? Any opinions are appreciated.

#2
Delphinus

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My most recent FBG is 117, and HBA1C is 5.3%. These numbers have been with me for past 2.5 years. My doctor now asks me to take 500mg Metformin, twice a day. I don't like to take any medication. In your opinion, should I take Metformin? I learned there is a Metformin extended release (ER) version, is Metformin ER better than Metformin? Any opinions are appreciated.


In my opinion, I don't see why you would need it.

I am not a doctor, but anyone, after seeing those numbers, would probably agree with me.

Maybe your doc is trying to pimp meds. I dunno. I can't see a doc suggesting metformin with those kinds of reasonable results over a period of time.

Tell him/her to get stuffed, or to explain why he/she is suggesting it.

Well, you can say the get stuffed part after he/she gives you a reason. :T
[SIGPIC][/SIGPIC]

Type1 diabetic. Son of a Type1 diabetic. Father to a Type1 diabetic.

+++ Jason

#3
GeorgeOttawa

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Thank you, Delphinus. In my Lab report, FBG between 110 and 125 is considered as impaired fasting glucose (pre-diabetes?). My doctor wants me to get my FBG below 110. Since diet and exercise can't do that, my doctor wants me to take metformin to bring my FBG to the target.

#4
GeorgeOttawa

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What is the percentage of pre-diabetes patients who take medications, few, 30%, half, 80%, or most?

#5
foxl

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Here is my angle: How is your weight? Would you like to lose some?

Metformin is helpful in controlling appetite, as long as you get along with it. I LOVE it.
Linda


[B]Jan A1c 6.3/B]
Jul 09 ... C-pep 1.3, GAD-65 > 30
Mar 10 C-pep 2.8 (20 g carb); GAD 3.2
dx 02/09 in DKA


Levemir 12U per day; novolog PRN TDD ca 16U
MetforminXR 1000 mg BID
Ramipril 5 mg
T4 112 mcg
Chia oil
Vitamin D3, 4000 IU
Eating 20 - 45 g carb per day ovo-lacto-vegetarian
Walking 30 min 6x week

#6
aggie168

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My most recent FBG is 117, and HBA1C is 5.3%. These numbers have been with me for past 2.5 years. My doctor now asks me to take 500mg Metformin, twice a day. I don't like to take any medication. In your opinion, should I take Metformin? I learned there is a Metformin extended release (ER) version, is Metformin ER better than Metformin? Any opinions are appreciated.


Your A1C is good. Your FGB can be just a "bit" lower. That is probably why your doctor suggest Metformin. 500mg is the lowest and it is a $4 generic at most drug store. It is also one of the older drug with a long track record so you should not have to worry about it as compare to many others. Like foxl said, if you can "handle" it, go for it. I went off it after 8 years due to GI problem. It causes one too many incident. :o

===============================================
DX 02/2002, Minimed 530G(751) w/CGMS on Novolog
Aspirin 81mg + Lipitor 10mg + Losartan 50mg

05/2014 A1C 5.8 Chol=154 Trig=96 HDL=48 LDL=87


#7
Abra

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Just on the Metformin ER part, I started it 3 days ago, at the 500 mg dose. No side effects at all, but so far no BG effects either. And no reduction of appetite, I'm sorry to say. I know it takes weeks to become effective, so maybe later I'll see some of those other effects, but taken in the middle of dinner I feel fine with it.
Dx 7/09/09
A1c @ Dx 7.2
A1c 3/26/10 6.0
A1c 6/28 5.9
A1c 10/25 5.7
Lisinopril/HCTZ
Synthroid
Vitamin D
Metformin ER 2000

#8
GeorgeOttawa

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Thank you, FOXL and aggie168. I am 1.80m (~5'10") tall and my weight is 70kg (~154lbs), so my weight is okay, maybe I need to gain some weight. I know eventually I will have to take medications, but I want to delay this procedure as late as possible. Money is not a concern for my decision on this issue. My doctor is my family doctor, not specialist on diabetes, so I like to get some opinions from this forum.

#9
GeorgeOttawa

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Thank you, Abra for your useful information. Please update your Metformin ER effects on the FBG and others later.

#10
foxl

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Thank you, FOXL and aggie168. I am 1.80m (~5'10") tall and my weight is 70kg (~154lbs), so my weight is okay, maybe I need to gain some weight. I know eventually I will have to take medications, but I want to delay this procedure as late as possible. Money is not a concern for my decision on this issue. My doctor is my family doctor, not specialist on diabetes, so I like to get some opinions from this forum.


Not that there are not slim Type 2's ... but have you had a C-peptide and GAD-65 antibodies? Just in case ...
Linda


[B]Jan A1c 6.3/B]
Jul 09 ... C-pep 1.3, GAD-65 > 30
Mar 10 C-pep 2.8 (20 g carb); GAD 3.2
dx 02/09 in DKA


Levemir 12U per day; novolog PRN TDD ca 16U
MetforminXR 1000 mg BID
Ramipril 5 mg
T4 112 mcg
Chia oil
Vitamin D3, 4000 IU
Eating 20 - 45 g carb per day ovo-lacto-vegetarian
Walking 30 min 6x week

#11
GeorgeOttawa

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Not that there are not slim Type 2's ... but have you had a C-peptide and GAD-65 antibodies? Just in case ...


No, I didn't do those tests. What do you mean "Not that there are not slim Type 2's "? You mean a slim person can't develop Type 2 diabetes?

#12
foxl

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No, I didn't do those tests. What do you mean "Not that there are not slim Type 2's "? You mean a slim person can't develop Type 2 diabetes?


Oh, yes they CAN! It is just that it goes against stereotype -- including "clinical" (or eyeball) diagnosis.

I felt that MDs looked at me, I was obese (not very) and so they just assumed I was type 2. Well, I had pre-existing thyroid disease ... autoimmune disease ... and was diagnosed in Diabetic ketoacidosis, and I was just not so sure as they.

I nosed around the net, found this place and many, many articles on antibodies in adult-onset Diabetes ... so I figured out what to ask for ... it took me three MD appointments of asking, but I GOT it. Now I am on insulin in the hope of preserving my beta cells for later use!

This condition is not rare, either -- there are probably more people with LADA -- adult-onset autoimmune Diabetes, than there are with Type 1 of childhood.
Linda


[B]Jan A1c 6.3/B]
Jul 09 ... C-pep 1.3, GAD-65 > 30
Mar 10 C-pep 2.8 (20 g carb); GAD 3.2
dx 02/09 in DKA


Levemir 12U per day; novolog PRN TDD ca 16U
MetforminXR 1000 mg BID
Ramipril 5 mg
T4 112 mcg
Chia oil
Vitamin D3, 4000 IU
Eating 20 - 45 g carb per day ovo-lacto-vegetarian
Walking 30 min 6x week

#13
savvysearch

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Metformin can cause GI problems. Metformin ER is less likely to cause those problems.

You can ask your doc to refer you to a specialist. Personally, i think 117 is still too high. Of course deciding to take medication is a personal choice and you shouldn't let your doc pressure you into something you're worried about.

If I were in your situation, and diet/exercise is not bringing my FG down, I'd be more concerned about getting diabetes which is much more worrisome to me than the effects of metformin, which is probably the safest of the diabetes drugs. Speaking only personally, I wouldn't want to get diabetes one day and then think there was something I could have done about.

#14
GeorgeOttawa

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Thank you, foxl and savvysearch. You and others are much more knowledgeable than me. I am learning.

#15
Larry H.

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Something I haven't seen yet here is how many carbs are you taking during the day? Are you on a restricted carb diet that would allow your numbers to lower?

My numbers were higher than yours but after I started exercising and got my carbs in line with the ADA guidelines my fasting numbers steadily dropped eventually in to the 90's or once in a while lower.

I know from being around here a while that evidently their are a number of variations on the problem an some need different treatments than others.

Like was mentioned, many pre diabetic people here do prefer to not take drugs. I am in that category. But I have always said that if I had to do so I would. So far its not been something I have to do.

I am not really clear on why your numbers on the low end refuse to drop. What kind of numbers are you seeing after eating. Normally the morning number is an indicator of the carb intake during the whole day. If they are low also I am not exactly clear on the reasoning for drugs?

#16
GeorgeOttawa

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Thank you Larry H., I am on low carb diet (~80g per day), and walk for 15 ~ 20 minutes after dinner everyday. My after eating numbers are good (I think), normally, < 126 afetr 1 hr, and < 110 after 2 hr.

#17
GeorgeOttawa

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What are advantages/disadvantages of metformin ER over metformin? Thank you.

#18
Almond66

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I'm a prediabetic with fastings between the 80's to 110. I'm in the medical world and there is so much information about prediatetics developing plaque. I am fighting getting diabetes as much as possible. I have eaten healthy and exercised regularly with little effect on my weight. I was put on Metformin long acting and lost 10 lbs in 3 weeks. I do have some nausea occasionally but can live with it. My endo asked me if I wanted to try Victoza as it can actually protect your insulin making cells in your pancreas. I trust him and started it. My fastings are now in the 70's. I have zero appetite and have to force myself to eat. It's only been a week but I'll see how it goes. George, I'd go see an endo but with your fastings I know mine would treat.

#19
GeorgeOttawa

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Thank you, Almond66. After reading your and other replies here, I think I should take metformin. Probably I should go with extended release metformin instead of standard metformin. Maybe after few weeks, if my FBG is not dropping, I will go to see an endo.

#20
genie86333

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What are advantages/disadvantages of metformin ER over metformin? Thank you.


The main advantage seems to be that the metformin ER is less likely to upset your stomach.




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