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best time to take metformin?

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In your opinion, what time of day would be the optimal time to take 500mg of slow release metformin for maximum effect?

Thx in advance for all answers :)
Diagnosed 22nd June 2010 - A1C: 10.5
500mg Slow Release Metformin Day
06/22/2010: Fasting BS 311
07/16/2010: Fasting BS 140
07/20/2010: Fasting BS 120
9/7/2010: A1C: 6.2!
09/16/2010: Fasting BS 100



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Depends. Personally, my a.m. numbers are most problematic, so I take it at bedtime (around 10 pm). If you're worried about potential symptoms, bedtime might be good as well, as you'll be sleeping and not as aware of any nausea or stomach problems you might experience. BTW, I'm on metformin ER 500 mg twice/day.

T2, diagnosed 8/31/06.
Meds: Metformin-ER 500 mg twice daily, HCTZ 12.5 mg every other day for BP Enalapril 20 mg 1 daily (ace-inhibitor)
Diet: I eat to my meter, generally eating 75-100 carbs/day with the occasional splurge.



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I take 2000 mg/day of Met ER and split it by taking 2 in the morning when my feet hit the floor and 2 at bedtime. I accidentally skip that bedtime dose at least once a week (insert forehead smack here) but find that makes absolutely no immediate difference in my readings ... even for the one taken in the middle of the night ... but that I will get slightly higher numbers within the next day or so. I don't think Met is like aspirin (which enters your system and has a quick effect) -- I think as long as you feed it into your system on a regular basis that it does it's job and that when you take it probably isn't all that important as long as all the mgs get in there each day. At least it seems that way to me.

Diagnosed Apr '10
A1C 11.4 Apr '10
A1C 7.4 Jul '10
A1C 5.8 Nov '10
A1C 6.5 Feb '11 -- too many holiday goodies and living on the edge :T
After many changes meds are ...
Metformin ER 1000mg 2x
Januvia mg 1x
Lisinopryl HCTZ 1x (for BP)
Norvasc 1x (for BP)
Simvastatin (1x nightly)
81mg Aspirin 1x
Vit D (2000 mg)



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When it was first prescribed for me, I took 500mg of the ER in the morning with breakfast.....had some DP so dr added night dose, which I took at bedtime. When my rx was renewed by my new dr, I got the regular met, but I still take it at the same times.
"Livin' Life by the Drop" - SRV

Diagnosed T2 July 2008 -- Metformin 1000 mg:2xdaily/Prilosec/Celexa

A1c Jul '08 = 6.8
A1c March 2013 = 5.4




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I've always taken mine with breakfast and dinner (evening meal).



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It's always best to take it with food. If I were to only take it once, I would take it in the evening and hopefully that will help your fasting numbers to be lower.

I take Metformin twice a day 1,000 mg each time.

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I am type 2 diabetic since 2001. On Lantus, Humalog and metformin.  

My son also has type 1 diabetes