[BlueSky]

Originally Posted by lottadata

Actually there ARE differences in IR because there are many different CAUSES of IR. ...

... oh yes, but whether the insulin is injected or made by beta cells shouldn't make any difference. Having said that, I have also heard of people not being able to utilise analog insulins, but it is a rare exception.

[lottadata]

Analog insulins are NOT the same molecule as human insulin. They have one of the amino acids replaced with a different one.

No one really knows what the long term effects of using these insulins might be and there are fears that they may promote cancer etc.

[BlueSky]

Originally Posted by lottadata

Analog insulins are NOT the same molecule as human insulin. ...

That is of course true. But getting back to the original question, analog insulins are not thought to cause insulin resistance. If a T1 requires increasing amounts of an analog insulin to control blood glucose, it is because of the same kind of insulin resistance that affects T2s and non-diabetics. The number of insulin receptors on the cell surface is reduced, for reasons which as you say are not well understood. And more insulin is required to clear glucose out of the blood stream. As far as I know, there is no reason to believe that IR affecting insulin injecting T1s is any different to IR affecting T2s who produce all their own insulin. Nor, for that matter, is it any different to the insulin resistance that affects non-diabetic Syndrome X sufferers.

Having said that, it could turn out that the switched amino acid in analog insulins does in fact have an adverse metabolic affect And that this somehow causes insulin resistance. But these insulins have been used for a long time now, and as yet there is no evidence of this.

[lottadata]

Blue Sky,

I have a dramatically different response to Humalog compared to either Novolog or Apidra--it works so poorly for me that I cannot use it. Highs followed by lows no matter how I time it.

I though that it was just my body being weird, but have since heard from other people with MODY who have experienced the same problem with Humalog and do well on the other analogs.

I also hear occasionally from people who do better on Humalog than Novolog.

That is why I suspect that there can be individual problems with these analogs.

And the person whose experience I cited earlier is getting far better blood sugars, consistently, with R at about 1/3 the dose she was using of the other insulins. She walked the doses of them up so it wasn't a case of overdose, either.