[knight191]

If I'm thin and dx at the age 23 yrs old.
Now my TDD insulin is 30u.


Thanks

[BlueSky]

Anyone can be insulin resistant. With normal insulin resistance, the requirement is about half a unit of insulin per Kg of body weight a day. So how much do you weigh?

[knight191]

I weigh 50 Kg
I take humalog 5+5+5u and Lantus 14u >>> TDD is 29u
so total insulin is 0.58 u per kg

Do u combine bolus and basal?
Or count only basal?

Thanks

[knight191]

with LADA,Why I started with a large number of insulin ?

Most people started with 1-4 u daily but I started with shot 4 times daily and TDD with 29u to control my BS well

[lottadata]

A recent study of people with LADA found that they have a mixture of genes associated with BOTH Type 1 and Type 2 diabetes. But the genetic profile was significantly different from Type 1.

You might find this interesting:


Genetic Similarities Between Latent Autoimmune Diabetes in Adults, Type 1 Diabetes, and Type 2 Diabetes.
Camilla Cervin et. al. Diabetes 57:1433-1437, 2008

[trailrunner]

Hey , that article is from my alma mater! That's too cool ! Oh it's interesting article too.

[knight191]

"LADA shares genetic similarities with type 1 and type 2 diabetes"

So LADA may occur characteristic/symptom for both T1( insulin dependent ) and T2 (insulin resistant, high cholesteral, high blood pressure) right?

[DCaplinger]

Okay... any Type 1 can experience insulin resistance. This isn't limited to Type 1.5's. Type 1.5's are people who develop Type 1 diabetes over a much longer period of time. These people may or may not ever experience problems with insulin resistance, just like some Type 1's also occasionally experience resistance.

It is important to note, that the most prevalent cause of insulin resistance is obesity. That's one of the biggest reasons why it's so important to keep your weight in check and exercise (unless your sugars are above 300). Regardless, you should occasionally test for keytones if you are exercising.

I am a good example of this. I was 180 pounds at the time of diagnosis. I required very little insulin at first, because I was a thin person. I've since gained 80 pounds, and my ratio has gone from 3:15 to 7:15 (units:grams of carb).

Regards,

[BlueSky]

Originally Posted by knight191

with LADA,Why I started with a large number of insulin ?

Most people started with 1-4 u daily but I started with shot 4 times daily and TDD with 29u to control my BS well

That is a very quick onset. Sounds more like T1 to me.

[knight191]

Originally Posted by BlueSky

That is a very quick onset. Sounds more like T1 to me.

but my C-peptide 2 hrs after drinking Isocal is 1.01 (for T1, lower than 0.6) and I have no DKA in past 1.5 yrs without insulin.

[lottadata]

Obesity is often the RESULT of insulin resistance, not the cause.

Studies of lean relatives of people with Type 2 found that they had much higher insulin resistance already than people whose relatives did not have Type 2.

Here are some other causes of insulin resistance:

1. Dropping Estrogen levels. When I go off estrogen supplementation I have to boost my insulin dose. If I go back on it, it drops.

2. Increasing age. Almost all older adults become more insulin resistant, probably because of wear and tear on receptors.

3. Abnormally high adrenal hormones. Cushings disease causes dramatically high IR. The body is pumping out natural cortisone and that causes IR.

4. Drugs, including Beta Blockers, Statins, and SSRI antidepressants. Many of the most commonly prescribed drugs our society has become addicted to raise insulin resistance, sometimes dramatically. Anti-psychotics can turn a normal person into a Type 2 diabetic, permanently in as little as a month.

[boelkowj]

Is there a difference in so called IR to endogenous insulin vs exogenous insulin levels? The term IR means something different for example in an obese nondiabetic person compared to a type 2 with inherent IR by definition, and IR based on increasing need for insulin dose in type 1 or 1.5 diabetics. Am I missing something more basic here?

Larry

[BlueSky]

Originally Posted by boelkowj

Is there a difference in so called IR to endogenous insulin vs exogenous insulin levels? ...

Why should there be a difference? Insulin resistance is the inability of insulin to poke glucose into cells. Whether the insulin is naturally produced or injected is really besides the point. When animal insulins were used, incrementally increasing dosages was sometimes required because of autoimmune rejection problems. But this is not the case with modern "human" insulin.

[mortis505]

Question, your thinking you are resistand because you are using a total of 30 units a day? I was started on 33 per day and have still maintained that average amount. I am now on a pump and can easily see the numbers. Are you using more than you used to? If you are T1.5 your honeymoon may be ending which is why your requirements may be increasing.

[lottadata]

Originally Posted by BlueSky

Why should there be a difference? Insulin resistance is the inability of insulin to poke glucose into cells. Whether the insulin is naturally produced or injected is really besides the point. When animal insulins were used, incrementally increasing dosages was sometimes required because of autoimmune rejection problems. But this is not the case with modern "human" insulin.

Actually there ARE differences in IR because there are many different CAUSES of IR.

A friend of mine recently saw her extremely high insulin need drop dramatically after she switched from analogs to humulin (R) insulin. Her receptors don't seem to have been able to process novolog.

Abnormalities of cortical hormones can also cause IR.

Some people become more IR with high fat intake while others become LESS IR.

The more scientists study diabetes the more all the sound-bite versions of how it works are biting the dust.