[Rekarb]

I've been digesting this information and Subby's supposition of a "broken liver" makes more and more sense as I look through my numbers under various conditions. Gluconeogenesis seems to be very much at the center of this process, at least for me. I am, however, on Met and it wasn't until the Actos was added that my bg started down. I am will to believe that some part of the metabolic processes are being affected by this combination but it takes a shot of brandy to bring me down into a normal range. This suggests to me that another part of the gluconeogenesis process is still largely unaffected.

Of course, I'm thinking out loud here but I seem to remember reading somewhere about a research suggesting that glucotoxicity shutdown or altered some port or signalling that might affect this. Gonna have to go digging some more.

I'm sick with the flu right now so my bg has gone awry. The only thing that sets things back - you guessed it, a shot of brandy.

Mike

sick but kind of enjoying the brandy thing.