| When running high the damage is long term highs. However, if you run extremely high (say 500+) and have keytones, you may develope DKA which is the breaking down of cells. Basically your insides boiling so to speak. However, most can run 300 without a problem (I hit 300 probably twice a week and run 100-150 the rest of the time.)
Long term highs lead to major complications. Short term highs, not hitting DKA, just lead to headaches and maybe some anger and just general discomfort.
Now, I know you didn't ask this, but it's related. For lows it is just the opposite. Long term lows really don't cause any harm, as long as you can maintain that low without dropping lower. The problem in lows is related to short term lows where it could cause one to black out. That could cause danger to yourself or others, depending on what you are doing.
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~IR 1000 (Dec. 2002-Jan. 2005)
~IR 1200 (Jan. 2005 - ?)
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