[dgrilli]

This is great news. I first heard about this in the: insulin-pumpers-digest Friday, December 15 2006 Volume 10 : Number 220

I immediately came to post the entire article and August beat me to it.

This great news. Just think the active ingredient in Chilli Peppers of all things capsicum the active ingredient in Cap Stun ( A Mace Alternative Used by Law Enforcement)

Apparently they found more similarities between Type 1 and Type 2 than most would care to acknowledge.

This means the Science behind Insulow (R-ALA) + (biotin) isn't so crazy. Since this stuff was supposed to help repair nerves in addition to other things.

the nerves in the pancreas huh? wow who would have thought that. Little bit of Chilli Pepper to the nerves of the Pancreas and walaw the pancreas workk normally.

Whats wrong with giving it to us now?

Why wait 10 years and the Big Pharma to fight them? Big Pharma should be very afraid the cat is out of the bag.

Should I sell before the word gets out? I'm not an insider Just an outsider looking in. ( Martha Stewart eat your Heart out ha ha

[KickStart101]

Originally Posted by dgrilli

Why wait 10 years and the Big Pharma to fight them? Big Pharma should be very afraid the cat is out of the bag.

Hmmm, you have a point there. I sure hope that this one doesn't
quietly disappear into the Great Blue Yonder, like the many other
"cures" we've heard of through the years.

[DeusXM]

As ever, I'm cautiously optimistic. What works in mice generally doesn't work in people but it's a step in the right direction and I just hope it doesn't divert interest away from other methods in case this one doesn't work out.

In respect of the rebuilding of islet cells, there's a new medication called Exendin-4 which stimulates the growth of islet cells which has proved very promising once the mechanism that destroys those cells is blocked.

[Rob43]

Toronto, Canada (AHN) - Scientists may be one step closer to finding a cure for Type 1 diabetes.

New research at Toronto's Hospital for Sick Kids, being published in the journal Cell on Friday, reveals that diabetes may in fact be a disease of the nervous system, not the auto immune system as previously thought.

During the course of their research at the hospital, doctors injected diabetic mice with capsaicin (the active ingredient in hot chili peppers), and a neuropeptide substance, which seemed to reverse the disease.

According to Dr. Michael Salter, a pain expert and one of the lead researchers, "Mice with diabetes suddenly didn't have diabetes any more."

Although the researchers have to still confirm their findings in people, the doctors are optimistic the same connection between nerve endings and pancreatic performance exists in humans.

The doctor's discovery, while still in the nascent stages, could eventually provide a cure for the millions of people who suffer from diabetes, including the 41,000 Canadian deaths caused by Type 1 diabetes a year.

All Headline News - Canadian Scientists Close In On Diabetes Cure - December 17, 2006

[KickStart101]

Hi Rob: Ya we heard, thanks. I'm Happy to see ya. I was
wondering what happened to you. I hope that you are doing
Good.

[August]

Originally Posted by Rob43

Toronto, Canada (AHN) - Scientists may be one step closer to finding a cure for Type 1 diabetes.

New research at Toronto's Hospital for Sick Kids, being published in the journal Cell on Friday, reveals that diabetes may in fact be a disease of the nervous system, not the auto immune system as previously thought.

This is very good news. Let's hope is not just another one of those "Canadian Penny Stock Scams".

The important question is: Who funded the research??

[Jackets]

This announcement feels different from the others; I hope I'm not getting too excited about this...

But it wouldn't surprise me if a cure came from Canada afterall.

[KickStart101]

Originally Posted by August

This is very good news. Let's hope is not just another one of those "Canadian Penny Stock Scams".

Ouchie! Low blow. Just like the snake oil cures, eh? Wonder
where they learned that from.....

Originally Posted by August

The important question is: Who funded the research??

Most of the money donated comes from the Canadians. We
are a small population but we are also spunky and Very generous.

[Cjohnson202]

having just been diagnosed last month, i am pretty excited about this. Am I the only who felt like going to toronto (not that I don't live there already) and offer my services as a test patient right away? I mean inject me with this thing, and see if it works. Sure there could be dangerous side effects...but human testing two years from now seems too far away...

[xMenace]

Originally Posted by Cjohnson202

having just been diagnosed last month, i am pretty excited about this. Am I the only who felt like going to toronto (not that I don't live there already) and offer my services as a test patient right away? I mean inject me with this thing, and see if it works. Sure there could be dangerous side effects...but human testing two years from now seems too far away...

Pfft! If I had a quarter every time I felt that way ...

[JasonJayhawk]

Like August said, I'm sure the investors are watching this carefully. A cure would mean a loss of hundreds, if not, thousands of jobs, in the diabetes care industry for Type 1 diabetes.

I thought it was interesting that one of the articles said that it may help Type 2 diabetes, as well. I suspect this was added to help receive more funding, since Type 2 is where the money is at.

Deus also said he's being cautiously optimistic. I thought I'd see a lot more people saying the same. I guess it's been a while since we've seen any "new great news," and with it being a holiday season, it's hard to show skepticism.

There are several kinds of Type 1 diabetes, to my understanding. I wonder which "kind" this would work. I'd also like to know the "link" between this research and Dr. Faustman's (with the spleen cells) -- how is the biology related -- could they be triggering the same mechanism?

Another question to answer is, why do we form antibodies that are indicative of the presence of Type 1 diabetes? These antibodies tend to disappear or show up in a less significant quantity in people who have had Type 1 for several years (thus making this test not useful unless the person has recently been diagnosed).... so, how could we explain the antibody formation if this is a neurological basis? And why is there a significant link between Type 1 (autoimmune) and other autoimmune conditions, such as thyroid and even gluten sensitivity? Are these conditions colinked by coincidence, then?

I can't wait until we hear more. I would love to know the researchers behind the story, too -- are these scientists well-known and respected, or are they up and new-comers who are looking for money and a quick buck before they admit the results cannot be confirmed by other labs?

I'll have to admit, I had a lot of excitement when reading this, but after a few hours of trying to connect the science, there are just too many holes.

But you'd better believe I'll be in line with the rest of you for the cure if it works.

[E-NICE]

While this approach has me optimistic. I have one nagging question. What about the genetifc aspect of type one in humans? Even if you suppress the immune system and get the beta cells to regrow on a large enough basis, would that be permanent? The bad genes that got us in this mess are still there. Not to say Im a geneticist or anything like that, just something that came to mind.

[Phranky]

Originally Posted by JasonJayhawk

Like August said, I'm sure the investors are watching this carefully. A cure would mean a loss of hundreds, if not, thousands of jobs, in the diabetes care industry for Type 1 diabetes.

I thought it was interesting that one of the articles said that it may help Type 2 diabetes, as well. I suspect this was added to help receive more funding, since Type 2 is where the money is at.

Deus also said he's being cautiously optimistic. I thought I'd see a lot more people saying the same. I guess it's been a while since we've seen any "new great news," and with it being a holiday season, it's hard to show skepticism.

There are several kinds of Type 1 diabetes, to my understanding. I wonder which "kind" this would work. I'd also like to know the "link" between this research and Dr. Faustman's (with the spleen cells) -- how is the biology related -- could they be triggering the same mechanism?

Another question to answer is, why do we form antibodies that are indicative of the presence of Type 1 diabetes? These antibodies tend to disappear or show up in a less significant quantity in people who have had Type 1 for several years (thus making this test not useful unless the person has recently been diagnosed).... so, how could we explain the antibody formation if this is a neurological basis? And why is there a significant link between Type 1 (autoimmune) and other autoimmune conditions, such as thyroid and even gluten sensitivity? Are these conditions colinked by coincidence, then?

I can't wait until we hear more. I would love to know the researchers behind the story, too -- are these scientists well-known and respected, or are they up and new-comers who are looking for money and a quick buck before they admit the results cannot be confirmed by other labs?

I'll have to admit, I had a lot of excitement when reading this, but after a few hours of trying to connect the science, there are just too many holes.

But you'd better believe I'll be in line with the rest of you for the cure if it works.

I'm hoping that the loss in productivity, the cost of heathcare (especially in countries with Universal healthcare) will offset the loss of revenue's that treatment would generate.

And besides, it's not like there aren't multiple other chronic illnesses that can't be exploited by these companies.

Either way, let's hope we're seeing the beginning of the end.

[DeusXM]

the cost of heathcare (especially in countries with Universal healthcare) will offset the loss of revenue's that treatment would generate.

That's what I'm betting on. In the UK, the NHS is the major buyer of pharmaceutical products and as such can exert considerably more pressure on pharmaceutical companies, much more than collections of individuals can. State healthcare also means the State can also to some extent control the sort of research carried out. There's a reason islet replacement therapy and stem cell research are more advanced in the UK and Canada than anywhere else in the world.

[BriOnH]

Faustman's prediction of diabetics having many choices in which cure or therapy to recieve looks like it is coming to light. Looks like a mix and match will most likely occur.

Anyone that thinks this can be banned because of fiscal concerns is nuts. People like myself and many others will seek it and spread it. The after math will make a better economy and if such a war were to exist between diabetics and government, or any agency or people, the diabetics will win. In a landslide so big it wouldn't even last a week.

I'll just echo what Deus said too. Mice models to human models usually have very big obstacles. Hopefully they will be doing primate studies soon. These scientists often lack follow through. They need project plans that require results over certain time.