[E-NICE]

Genes Linked to Autoimmune Diseases - To Your Health - MSNBC.com

[Stuboy]

an interesting read... most of it went over my head, but i did try lol

[Starlight]

Theres just so much research out there on the causes- autoimmune, neurologic, genetic...It confuses me & scares me to think they'll find the cure for one category and I'll be left out..Man now THAT would suck..

[erich]

Pilot study provides diabetic patients and caregivers with high-tech approach to monitoring and care



Wilfrid Laurier University - Headlines

[oneluckyplay]

thought i read that the inflammation kills all of the insulin producing genes. so how is that going to help a mouse that has no islet genes left(let alone a human with no islet genes left).

[designdb]

You know guys believe me I don't want to be negative about this but having Diabetes for 37 yrs, it's the same old story, I hate to tell this especially to the new comers of the disease.

Don't get your hopes up, just live your lives and get a good doctor who will NOT steer you in the wrong direction far as your health. Don't eat sugar, well except for natural sugars like in fruits, and keep your blood sugar in the normal range and exercise. If you follow this you will be successful in your adventure and be healthy which as you know is the most important thing.

[BriOnH]

Originally Posted by E-NICE

Genes Linked to Autoimmune Diseases - To Your Health - MSNBC.com

What exactly is wrong with the genes in these regulatory T cells? What are they doing that they shouldn't be doing?
Young: In autoimmune disorders, most of these genes are less active than they normally would be. What Alex and his colleagues discovered is that this turns the regulatory T cells' activities down, so they're not as aggressive or powerful as they normally would be. Now, it was only three years ago that scientists discovered the "brain" of the regulatory T cells, or the gene that tells them how to do their job. This is a gene called Foxp3.

So Foxp3 is the immune system's big boss, and the 30 genes you've found inside the regulatory T cells are the middle managers?
Young: Right. Until now, it was not known exactly how Foxp3 was giving these T cells directions—which genes it was controlling in order to do that.

That last paragraph really hit home. I hope we can learn to minipulate these genes. Faustman is doing it. I wonder if she is making any more progress.

[BlueSky]

Originally Posted by designdb

..... Don't get your hopes up, just live your lives and get a good doctor who will NOT steer you in the wrong direction. .....

I feel this way too, after having been T1 for 30 years. Lots of people seem to be having lots of interesting ideas about finding a permanent solution to T1. But I don't expect a cure within my lifetime. Even if a "cure" did come along, I don't know that I would want to try it if it involved messing with my immune system and my genes. Better the devil you know than the one you don't. I have done OK on MDI so far. And I will be able to keep it up for the next 30 years.

Having said that, I think research in all areas of human endeavour is great. And I salute those who can get excited about it.

[momtomadison]

It would be nice to hear some updated information on this research. Anyone have anything?

I get ancy when I hear great news in diabetes research, and then nothing. I know it hasn't been too awful long ago, but SOMETHING would be nice.

like, where are they going with it now?

When are we going to see some capsacian injections? lol

[JasonJayhawk]

Here's random articles I've come across--not sure if they've been mentioned already.

1. Revimmune Uses An Approved Drug In A New Patent-Pending Method To Eliminate Autoimmunity

My comments: Basically, the article makes mention of treatment of Type 1 diabetes by "rebooting" the immune system with an already-approved drug. They report that this process has been successful with other autoimmune conditions, like MS, MG, and RA.

Even though juvenile diabetes is mentioned, no studies have been made with it.

I get uncomfortable when too many forward-looking statements are made in a single press release.

2. Diamyd Medical Announces Phase III Clinical Trials Plan For Diamyd(R) In Type 1 Diabetes

My comments: This article mentions a drug from Diamyd Medical that deals with the GAD65 autoantigen. It's interesting to note that they report that the GAD might have a roll in other CNS-related diseases. This links back to the news reported earlier about another research group thinking that Type 1 has a neurological component.

[BlueSky]

Originally Posted by JasonJayhawk

..... This links back to the news reported earlier about another research group thinking that Type 1 has a neurological component.

I was reading an article on neurofeedback in which it was suggested that this technology can be used in the treatment of type 1 diabetes. The notion seemed a bit off-the-wall to me. So I did a search and found this:

In the case of Type I diabetes, a condition in which the body has lost its ability to fabricate insulin by virtue of autoimmune disease, EEG biofeedback training can provide a greater tolerance to variations in glucose level. Subjects report being more energetic and robust.

EEG Spectrum International - Introduction to Neurofeedback and Autoimmune Dysfunction

Interesting. I have been considering using neurofeedback to deal with an attention issue. Maybe it would somhow help dealing with glyceamic control too. Anyone have any comments?

[msrkBen]

All I have to say is, "I'll believe it when I see it."

[JasonJayhawk]

Originally Posted by BlueSky

I
I have been considering using neurofeedback to deal with an attention issue. Maybe it would somhow help dealing with glyceamic control too. Anyone have any comments?

It sounds like some kind of stress management -- having low(er) stress would probably improve glycemic control.

Not sure I'd spend money on their technique.

As far as your attention issue...there could be a many reasons to consider! (Sleep apnea, stress, adult-onset ADD, thyroid hormone imbalance, all for starters).

[KickStart101]

Originally Posted by momtomadison

It would be nice to hear some updated information on this research. Anyone have anything?
I get ancy when I hear great news in diabetes research, and then nothing. I know it hasn't been too awful long ago, but SOMETHING would be nice.
like, where are they going with it now?
When are we going to see some capsacian injections? lol

I did e-mail CBC about any updates a while back
but I haven't heard anything back yet. Probably
means they haven't heard anything either. I also
tried googling for updates but I haven't found the
key words yet. Someone in Toronto oh say "Injecto"
might have an easier go at any info. Then again,
maybe not.


Well, I'd rather feel hopeful than hopeless.

I did find the Person responsible for info and
updates concerning the Diabetes Reversal
Research. I sent her an e-mail requesting
any updates she could offer. I told her
about Tony's Forums and gave her the site
address. I also gave her my e-mail address.

Unfortunately, I don't think we will receive any
updates since they probably do not give them
to civillians(sp). That would take a lot of Staff
to e-mail every one.

Instead it seems like most businesses, when
they have worthwhile updates they then call
whatever media outlets have asked to be called
and give them the news first. Then the media
puts it out to the public.

They are continuing the research and will be
extending it to Humans when it is the right time.

[erich]

Some updates on the canadian sensory neurons discovery


some updates on the canadian sensory neurons discovery

Erich J. Knight