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12-19-2007, 01:11 PM
|  | Senior Member
I am a: Type 1 | | Join Date: Sep 2006 Location: Auckland, New Zealand
Posts: 2,156
| | | Drug stops the auto-immune attack
I found this really interesting ... Quote: |
Experimental drug DiaPep277 has been shown in a Phase II human clinical trial to arrest the progression of type 1 diabetes, prevent destruction of insulin-producing pancreatic cells, and reduce the need for injected insulin in newly diagnosed patients ....
| New Collaboration For Possible Type 1 Treatment with DiaPep277
This medication could be good for people who have just been diagnosed. Now if only they would put as much effort into figuring out what caused the auto-immune attack in the first place. ....
__________________
In my humble opinion  
Type1 since 1977
MDI using Lantus, Novorapid and Actrapid
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12-19-2007, 02:12 PM
|  | Senior Member
I am a: Type 1 | | Join Date: Dec 2007 Location: Landenberg, PA
Posts: 1,337
| | | Ain't THAT the truth.
I read some months ago that experiments injecting (installing?) islet cells into the liver of (sadly a very few) subjects was successful as the islet cells were adopted and grew in the liver.
Sign me up! |
12-19-2007, 04:02 PM
|  | Senior Member
I am a: Type 1 | | Join Date: Sep 2005 Location: Cincinnati, OH
Posts: 8,367
| | Quote:
Originally Posted by morrisma  Ain't THAT the truth.
I read some months ago that experiments injecting (installing?) islet cells into the liver of (sadly a very few) subjects was successful as the islet cells were adopted and grew in the liver.
Sign me up! | That has been successful to a degree. However, the patients are required to take immunosuppressent drugs that have very risky side effects. Also, there is no guarantee of how long it will last and I know less than a handful have been insulin free for more than 5 years.
Newer drugs hold the only promise until what causes it is discovered. Which will only happen with better research into people before they get diabetes.
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●Blue Ash, Ohio Police Dispatcher
●Type 1 diabetic for 25 years (11 months old)
●Animas pumper since December of 2002
~IR 1000 (Dec. 2002-Jan. 2005)
~IR 1200 (Jan. 2005 - ?)
●LifeScan OneTouch UltraSmart Diabetes is an Art, NOT a Science. You must master the control by skills and not by knowledge alone. |
12-19-2007, 04:44 PM
| | Senior Member
I am a: Type 1 | | Join Date: Sep 2006 Location: Auckland, New Zealand
Posts: 2,156
| | Quote:
Originally Posted by JediSkipdogg ... the patients are required to take immunosuppressent drugs that have very risky side effects. .... | That problem is not insurmountable. Good progress has been made on protecting implanted cells with alginate micro-encapsulation LCT - Living Cell Technologies - Biotechnology in Australia, Italy, New Zealand, USA. The biggest problem is finding a supply of beta cells. Getting them from pigs is viable, but negotiating through the xenotransplantation issue will take time ... 
There is also the prospect of producing more targeted and less risky immunosupression drugs. The Springer Point Project is going this route Who We Are. You can sponsor a pig through their website  .
__________________
In my humble opinion
Type1 since 1977
MDI using Lantus, Novorapid and Actrapid
|
12-19-2007, 05:54 PM
|  | Member
I am a: Type 1 | | Join Date: Nov 2007 Location: Mid-Missouri
Posts: 223
| | Quote:
Originally Posted by BlueSky | That sounds like a very promising and practical hope for us type 1's. I remember hearing something about encapsulating islets with some sort of algae about 10 years ago, and thought it was just another one of those things that was forgotten about. I read from the article on the site that the expected sales of the development (assuming everything goes well) are 2011/2012. I can wait that long, and would be happy to fly to Russia to have the procedure done. I guess I better not get my hopes up though. But hey, at least steps are being made. Thanks for the post Bluesky.  |
12-19-2007, 06:48 PM
| | Senior Member
I am a: Type 1 | | Join Date: Sep 2006 Location: Auckland, New Zealand
Posts: 2,156
| | Quote:
Originally Posted by kstreeter513 ... I ... would be happy to fly to Those Russia to have the procedure done. .... | The Russian trials have been promising ... Quote:
Professor Bob Elliot, Medical Director of LCT, announced that a third patient in the Russian clinical trial was implanted with the first dose of DiabeCell® and is due for a second dose in six months. DiabeCell® is administered to patients without the need for immunosuppressant drugs.
The first patient, implanted with DiabeCell® in June 2007, has maintained a 40% reduction in his insulin requirement at five months follow-up. This patient is due for a second dose of DiabeCell® in December.
The second patient, having received only the first dose of DiabeCell® in September 2007, remains insulin independent at two months follow-up.
| The next phase of the trials is expected to take place in Auckland (I have already made myself available ). But these things seem to take an enormous amount of time. The initial trials were stopped 10 years ago because of the xenotransplantation debate. The government has given approval for their resumption, but final sign-off of by the minister of health is still outstanding. And 2008 will be election year ... so I am not holding my breath 
__________________
In my humble opinion
Type1 since 1977
MDI using Lantus, Novorapid and Actrapid
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