[HollyB]

The other thing is that even if the Lantus released perfectly steadily over 24 hours, that's not what everyone needs. That becomes really apparent when you start figuring basals on a pump - my son, for example, needs half the basal between about 10 pm and 2 pm that he does at other times. So if you have a tendency to run low at night, and high in the daytime (or vice-versa), two doses of Lantus might allow you to fine-tune to your basal needs a little better.

[SuzySushi]

For my 13 y.o. daughter, Lantus lasts something like 20 to 22 hours, not 24. Her dose is split with about 70% given at dinnertime and the remaining 30% given at breakfast. That way the doses are given approximately 12 hours apart. The theory is that the breakfast Lantus boosts her basal insulin coverage during the afternoon so that it won't wear off before or during dinner. She also takes NovoLog at each meal.