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11-06-2008, 01:24 PM
|  | Senior Member
I am a: Type 2 | | Join Date: Oct 2007 Location: Vermont
Posts: 2,291
| | | Motor protein Myo1c is key to insulin resistance
Not a cure. but a "significant clue" to T2 Completely Novel Action Of Insulin Unveiled
ScienceDaily (Nov. 6, 2008) — A Ph.D. student at Sydney's Garvan Institute of Medical Research has uncovered an important piece in the puzzle of how insulin works, a problem that has plagued researchers for more than 50 years. The research brings scientists one step closer to explaining exactly how insulin prompts fat and muscle cells to absorb glucose.
...
"I have discovered that insulin activates a specific kind of motor protein known as Myo1c, which in turn performs a critical role in glucose uptake."
Insulin controls glucose uptake into our fat cells by moving glucose transporter proteins from inside the cell to the surface membrane so that they can pump glucose into the cell. Myo1c aids in this process by helping the transporters slide into the surface membrane.
In healthy people, around 80% of the glucose transporters migrate to the cell membrane after a meal, allowing plenty of glucose into the cell. In people with Type 2 diabetes, however, that figure drops to around 10%...
(link)
__________________ Either write something worth reading or do something worth writing. -- Benjamin Franklin |
11-06-2008, 01:30 PM
|  | Senior Member | | Join Date: Jun 2008 Location: Chandler, AZ
Posts: 1,079
| | That was very interesting, thank you for posting! 
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Jill
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11-06-2008, 01:35 PM
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I am a: Type 2 | | Join Date: Mar 2008 Location: Alabama
Posts: 1,077
| | | Fascinating! Not a cure, but perhaps hope for a really effective treatment. Maybe something that helps the MYO1C levels. Thanks for posting!
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Glycemic impact diet
exercise
Metformin 2000 mg
Byetta 10 mcg/2x daily
Enalapril 40 mg
A1C, 9-1-09: 5.3!! 
A1C, 5-19-09: 5.1!!! 
A1C, 2-12-09: 5.3!! 
A1C, 11-14-08: 5.2!!
A1C, 8-7-08: 6.3 
A1C, 5-1-08: 5.6!! 
A1C, 2-5-08: 7.4  |
11-06-2008, 02:06 PM
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I am a: Pre-Diabetic | | Join Date: Oct 2008 Location: Kitchener, Canada
Posts: 275
| | | Very interesting. Thank you Keith.
Regards,
Rad
__________________  Two houses, half a globe apart, that I call my own.
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11-06-2008, 02:27 PM
| | Senior Member | | Join Date: Jan 2008
Posts: 1,242
| | | Wow. Good reading. Many thanks for sharing! |
11-06-2008, 03:55 PM
| | Senior Member | | Join Date: May 2007 Location: california
Posts: 1,013
| | | exciting to know new things are being found all the time...thanks for sharing...boy i sure do learn a whole bunch from you guys!!!
susan |
11-06-2008, 05:55 PM
| | Senior Member
I am a: Type 1.5 | | Join Date: Feb 2008 Location: RURAL NSW AUSTRALIA
Posts: 883
| | Hi
Wow is that interesting to reduce insulin resistance would be fantastic. Keith thanks for sharing this
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11-06-2008, 06:04 PM
| | Senior Member
I am a: Type 2 | | Join Date: Mar 2008 Location: Nova Scotia, Canada
Posts: 5,266
| | | Interesting article Keith... Thanks. Although I sometimes wonder if the scientists are not focusing on the wrong details - this may explain the mechanism that is effected in IR, but why do we get IR in the first place?
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Frank
51 year old male, Metabolic Syndrome Dx Mar. 2003 |
11-06-2008, 06:28 PM
| | Senior Member
I am a: Type 2 | | Join Date: Oct 2007 Location: Vermont
Posts: 2,291
| | Quote:
Originally Posted by fgummett  Interesting article Keith... Thanks. Although I sometimes wonder if the scientists are not focusing on the wrong details - this may explain the mechanism that is effected in IR, but why do we get IR in the first place? | You'll agree Frank, that there is much debate about what causes IR. Debate because frankly, ( ) we don't know exactly what causes IR . Why not look at this as a step toward finding out? 
Perhaps we have to understand IR in order to resolve the debate about what causes it. I won't rule out that there may be manifold causes. 
__________________ Either write something worth reading or do something worth writing. -- Benjamin Franklin |
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