[carlisleguy]

I recently started peritoneal dialysis (PD) and have been getting excess bloo d glucose readings. I know that the fluid I use is causing this, but wander if anyone else has had such an experience. I have increased my lantus, but still need to use humolog during the night. Bg readings in the high 300's and sometine over 400. I guess my question is... How do others cope with this siituatiion? Thanks in advance.

[Jan B]

It sounds like you'll need to do some basal testing and then decide how much more you might need to raise your Lantus. (?) I was reading about the PD and diabetics having high bgs along with it. I did see that the solutions vary in the amount of dextrose from 1.5 (yellow bag) to 4.25% (red). Hopefully you are using the lower % bag?

What a pain to need to start over with your insulin requirements. I'm wishing you strength and I hope you will be feeling better after getting your bgs settled back down. I would be slowly increasing my insulin until I could be looking at better readings.

Maybe someone will come along who has experienced this . . .

[lorilei]

Hi Car..you may want to post this on the reg diabetes thread bc there may be some long term 1's or 1.5er's with some experience in this..it sure does sound rough to have those numbers at the same time you are starting dialysis...can you tell us more about yourself..regimine and reg BG numbers for you?

[imac]

I hope that some one can give you some advise on this as I am about to start PD. I did not think that it would affect your blood glucose. As I am on insulin you would have thought the kidney specialist would have mentioned this.

[EeyoreButterfly]

What kind of meter are you using. Recently the FDA issued an advisory that some meters give false highs when certain substances are in the body. Dialysis was one of the contraindications. They said this is particularly dangerous for people on insulin because it is causing them to overtreat and drive themselves low.

I know for sure that Freestyle is on the list. I forget the others. I believe AccuChek is on the list too. I remember seeing a notice at a lab reminding workers not to use it on people who were receiving dialysis. One Touch meters are not on the list, they will not give you a false high.

Check your meter first and make sure it is not one of the meters under advisory. I will try to dredge up the link.

[EeyoreButterfly]

Found it!

Please read this and make sure it doesn't apply to you before adjusting your insulin.

For
Diabetic patients and/or their caregivers

Advice
NEVER use GDH-PQQ* glucose meters or test strips if you are using drug products or therapies that contain certain sugars other than glucose.

*GDH-PQQ stands for glucose dehydrogenase pyrroloquinoline quinone

Issue
Diabetic patients who receive drug products or therapies containing certain sugars other than glucose could experience serious, although rare, injuries if they use blood glucose meters with a particular type of test-strip technology. Strips that use this technology, known as GDH-PQQ, will react with certain non-glucose sugars, including maltose, galactose and xylose, and produce a falsely high (elevated) result. If a diabetic patient then takes too much insulin because of this falsely high result, it could lead to abnormally low blood sugar (hypoglycemia), coma, or even death.

Certain patients may be more likely to be using drug products or therapies that contain other sugars, including those who:

are on peritoneal dialysis
have recently had surgery
Glucose test strips other than the GDH-PQQ type are not affected by this problem, and can be used by patients taking drug products or therapies that contain non-glucose sugars.

List of GDH-PQQ test strips and their associated meters
List of GDH-PQQ Glucose Test Strips

Drug products or therapies with non-glucose sugars
Extraneal (icodextrin) peritoneal dialysis solution
Some immunoglobulins: Octagam 5%, Gamimune N 5% **, WinRho SDF Liquid, Vaccinia Immune Globulin Intravenous (Human) and HepaGamB
Orencia (abatacept)
Adept adhesion reduction solution (4% icodextrin)
BEXXAR radioimmunotherapy agent
Any product that contains, or the body breaks down into, the sugars maltose, galactose or xylose
** Within the U.S., Gamimune N 5% has not been manufactured since December 2005, and no lots are in distribution in the U.S.

Patient concerns
If you are taking drug products or therapies that contain certain non-glucose sugars, such as maltose, galactose and xylose, these sugars will produce a falsely elevated glucose result if you are measuring your blood glucose using a GDH-PQQ test strip. If you then use this falsely elevated result to determine your dose of insulin, you could give yourself too much insulin, which could result in dangerously low blood glucose. In addition, if your blood glucose is actually low, it could go unrecognized and untreated because the test result could read higher than it actually is and appear to be within the normal range. In this case, you may not know your blood glucose is low unless you have certain symptoms, including confusion, hunger, nervousness, dizziness, irritability, sweating, heart pounding (palpitations), shaking, unusual fatigue or weakness, or tunnel or darkened vision. Low blood glucose must be recognized and treated promptly to avoid serious complications, such as coma and death.

Recommendations for diabetic patients using interfering drug products or therapies
If you are a diabetic patient who uses any of the drug products or therapies that contain certain non-glucose sugars (or care for someone who does), you should:

NEVER use GDH-PQQ glucose meters or test strips.
Instead, use another type of glucose monitoring technology and continue to monitor your blood glucose as instructed by your healthcare provider.
Contact your healthcare provider if your results do not reflect the way you feel.
You may be able to determine the type of glucose monitoring technology you are using by looking at the instructions that accompanied your meter or test strips, or at your meter’s box. If you can’t tell what kind of technology your meter and test strips use, ask your healthcare provider or pharmacist to help you find out, and/or contact the manufacturer of your meter and test strips.

General recommendations for all diabetic patients
Continue testing your blood glucose as directed by your healthcare provider.
Use only test strips specified for your glucose meter.
Know the type of glucose monitoring technology you are using.
Know that GDH-PQQ meters and strips should NOT be used if you are using an interfering drug product or therapy.
Know that GDH-PQQ meters and strips are okay to use if you are not using an interfering drug product or therapy.
Know the medications you are taking and keep a current list of your medications. If you do not have a current list of medications, ask your healthcare provider to provide you with a list.
Reports received by FDA
From 1997 - 2009, FDA received 13 reports of death associated with GDH-PQQ glucose test strips in which there was interference from maltose or other non-glucose sugars. The deaths occurred in healthcare facilities. Some reports indicated that serious patient injury, such as low blood glucose (hypoglycemia), confusion, neurologic deterioration, too little oxygen in the tissues (severe hypoxia), brain damage and coma, occurred prior to death.

FDA is working with manufacturers to resolve the problems with GDH-PQQ glucose test strips, and is continuing to monitor adverse events associated with these products.

Questions to ask your healthcare provider
How do I determine which glucose meter and strips I have?
Which drugs am I currently taking? Am I taking or receiving an interfering drug product or therapy?
Should I continue testing my blood glucose with my current meter and strips or should I get a new meter and strips? If so, how do I do this?
For more information see FDA Public Health Notification: Potentially Fatal Errors with GDH-PQQ Glucose Monitoring Technology.

Reporting adverse reactions
Consumers may report adverse reactions related to glucose meters or glucose test strips to FDA’s MedWatch Adverse Event Reporting Program online, by phone, FAX or mail.

Online: MedWatch: The FDA Safety Information and Adverse Event Reporting Program
Phone: 1-800-332-1088
FAX: 1-800-FDA-0178
Mail: use postage-paid FDA form 3500 mail to MedWatch, 5600 Fishers Lane, Rockville, MD 20852-9787

--------------------------------------------------------------------------------

List of GDH-PQQ Glucose Test Strips
The following test strips (with associated meters) use GDH-PQQ methodology as of August 2009:

Roche Diagnostics:
ACCU-CHEK Comfort Curve test strips, for use with:
ACCU-CHEK Inform meters [model 2001201]
ACCU-CHEK Complete meters [models 200 and 250]
ACCU-CHEK Advantage meters [models 888, 831, 850, and 768]
ACCU-CHEK Voicemate meters [model 0009221]
ACCU-CHEK Aviva test strips, for use with:
ACCU-CHEK Aviva meters [models 525, 535, and 555]
ACCU-CHEK Compact test strips, for use with:
ACCU-CHEK Compact meters [model GF]
ACCU-CHEK Compact Plus meters [models GP and GT]
ACCU-CHEK Go test strips
ACCU-CHEK Go meters [model GJ]
ACCU-CHEK Active test strips
ACCU-CHEK Active meters [models GG and GN]
Abbott Diabetes Care:
Freestyle test strips, for use with:
FreeStyle meters
FreeStyle Flash meters
FreeStyle Freedom meters
Freestyle Lite test strips, for use with:
FreeStyle Lite meters
FreeStyle Freedom Lite meters
Home Diagnostics:
TRUEtest test strips
TRUEresult meters
TRUE2go meters
Smiths Medical:
Abbott Diabetes Care Freestyle test strips, for use with:
CoZmonitor blood glucose module (for use with the Deltec Cozmo Insulin Pump)
Insulet:
Abbott Diabetes Care Freestyle test strips, for use with:
OmniPod Insulin Management System
Note: Test strips currently on the market may be distributed under multiple trade names. In addition, manufacturers of GDH-PQQ test strips currently on the market may subsequently change to non-GDH-PQQ methodology. Therefore, healthcare providers (and patients) should refer to device labeling or consult with test strip manufacturers to confirm the type of methodology used.

[imac]

I had a phone call to accu-chek, as I have 3 accu-chek meters and use their software. They have told me their meters work if you are on PD but you have to use special strips which they are going to supply for free. Them supply something for free?

[carlisleguy]

Originally Posted by imac

I hope that some one can give you some advise on this as I am about to start PD. I did not think that it would affect your blood glucose. As I am on insulin you would have thought the kidney specialist would have mentioned this.

----------------------------------------------
Thanks, that is good info. I use the onetouch meter, but if you can find the FDA link I would appreciate it. That sounds like a good reference. Thanks again.

Carlisle Guy

[carlisleguy]

Originally Posted by EeyoreButterfly

What kind of meter are you using. Recently the FDA issued an advisory that some meters give false highs when certain substances are in the body. Dialysis was one of the contraindications. They said this is particularly dangerous for people on insulin because it is causing them to overtreat and drive themselves low.

I know for sure that Freestyle is on the list. I forget the others. I believe AccuChek is on the list too. I remember seeing a notice at a lab reminding workers not to use it on people who were receiving dialysis. One Touch meters are not on the list, they will not give you a false high.

Check your meter first and make sure it is not one of the meters under advisory. I will try to dredge up the link.

-----------------------------------------------------
Thanks, that's good info. I do use the OneTouch meter. If you locate the FDA link, please post it as this seems like a good resource. Thanks.

CG

[carlisleguy]

Originally Posted by EeyoreButterfly

Found it!

Please read this and make sure it doesn't apply to you before adjusting your insulin.

Thanks, again. It looks like my OneTouch Ultra meter, by Lifescan isn't on the list. I wonder how many doctors are aware of this problem?

CG

[imac]

I got a list of meters that you can use from Baxter Health who supply the dialysis fluid. I am a bit disappointed in the doctors who do not seem to know about this problem. By the way the list from baxter is country specific as we all use different meters.