I started 5 mg a day of glipizide a week ago. I take it along with 2000 mg of Metformin. While I haven't experienced any weight "gain", I've been working out everyday, struggling to walk 6 miles a day and I haven't lost any weight. Typically I lose at least 1lbs or more a week, but I actually think I've gained weight over the past two weeks. uggg... but I'm a little relieved that it's not just me. This is part of the reason I joined the forum... to read about other peoples experience with glipizide.