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shel

What is Type 1.5 Diabetes

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Until signing on here a few days ago, I never heard of Type 1.5 diabetes. Can anyone tell me what it is and how it differs from Type 1 and Type 2? Thanks

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I am a type 1.5. I was diagnosed at age 28 and started on pills, they worked for a short time than quickly my bs went up. I than started on insulin with in 3 years of being diagnosed.

 

Mr. Endo. explains it as my panc. is basically teatering out and not producing insulin. Although I still have eyelet (sp?) cells.

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Type 1.5 is referred to as "LADA" or "Latent Autoimmune Diabetes in Adults".

 

Diabetes Monitor describes LADA as follows:

 

Latent Autoimmune Diabetes in Adults (LADA) is a form of autoimmune (type 1 diabetes) which is diagnosed in individuals who are older than the usual age of onset of type 1 diabetes (that is, over 30 years of age at diagnosis). Alternate terms that have been used for "LADA" include Late-onset Autoimmune Diabetes of Adulthood, "Slow Onset Type 1" diabetes, and sometimes also "Type 1.5 [Type one-and-a-half]" diabetes.

 

Often, patients with LADA are mistakenly thought to have type 2 diabetes, based on their age at the time of diagnosis. Such misdiagnosis is easy to make when the person is older, and initially responds to treatment with diabetes pills. It is now thought that perhaps twenty percent of patients with apparent Type 2 diabetes really have LADA.

 

Patients with LADA do not have insulin resistance, as do people with Type 2. Also, positive antibody tests would help make the diagnosis of LADA in a person who might be suspected of having either LADA or Type 2.

 

Some diabetes specialists feel that once LADA is diagnosed, it is important to promptly start the patient on insulin therapy (rather than using sulfonylureas or other diabetes pills), but it is unclear whether early treatment with insulin is beneficial for the remaining beta cells.

 

Drug therapy to preserve insulin function in patients with LADA is being investigated.

 

Characteristics of LADA

 

* Adult age at diagnosis (usually over 25 years of age)

* Initial presentation masquerades as non-obese type 2 diabetes (does not present as diabetic ketoacidosis)

* Initially can be controlled with meal planning with or without diabetes pills

* Insulin dependency gradually occurs, frequently within months

* Positive antibodies

* Low C-peptide levels.

* Unlikely to have a family history of type 2 diabetes.

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I think I might have type 1.5 as I was diagnosed with type 1 at 30 years old. I also use low amounts of insulin.

 

To answer your question, I believe I had hypos in the 8 years leading up to being diagnosed. The doctors kept telling me I had panic attacks because the symptoms of hypos and panic attacks are similar I guess. When I started on insulin and had a blood glucose meter I was able to start checking my blood glucose when my breathing got faster. The 'fast breathing' was always a hypo. It was great when I started eating in response to hypos and the breathing symptoms went away!

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EB, I had reactive lows (and highs) for years, and i would say that they were pretty much self-induced as i had frightful eating and dieting habits...but yes, before that period in my life and after it, i have always been "susceptible" to carbs and sudden changes in bg both high and low....this came out again to haunt me with pregnancy, but now i wonder if it was not really gestational diabetes, but the precursor or slow build up of an automimmune attack..i slide from one state to the other.

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Type 1.5 is referred to as "LADA" or "Latent Autoimmune Diabetes in Adults".

 

Diabetes Monitor describes LADA as follows:

 

Latent Autoimmune Diabetes in Adults (LADA) is a form of autoimmune (type 1 diabetes) which is diagnosed in individuals who are older than the usual age of onset of type 1 diabetes (that is, over 30 years of age at diagnosis). Alternate terms that have been used for "LADA" include Late-onset Autoimmune Diabetes of Adulthood, "Slow Onset Type 1" diabetes, and sometimes also "Type 1.5 [Type one-and-a-half]" diabetes.

 

Often, patients with LADA are mistakenly thought to have type 2 diabetes, based on their age at the time of diagnosis. Such misdiagnosis is easy to make when the person is older, and initially responds to treatment with diabetes pills. It is now thought that perhaps twenty percent of patients with apparent Type 2 diabetes really have LADA.

 

Patients with LADA do not have insulin resistance, as do people with Type 2. Also, positive antibody tests would help make the diagnosis of LADA in a person who might be suspected of having either LADA or Type 2.

 

Some diabetes specialists feel that once LADA is diagnosed, it is important to promptly start the patient on insulin therapy (rather than using sulfonylureas or other diabetes pills), but it is unclear whether early treatment with insulin is beneficial for the remaining beta cells.

 

Drug therapy to preserve insulin function in patients with LADA is being investigated.

 

Characteristics of LADA

 

* Adult age at diagnosis (usually over 25 years of age)

* Initial presentation masquerades as non-obese type 2 diabetes (does not present as diabetic ketoacidosis)

* Initially can be controlled with meal planning with or without diabetes pills

* Insulin dependency gradually occurs, frequently within months

* Positive antibodies

* Low C-peptide levels.

* Unlikely to have a family history of type 2 diabetes.

 

 

First, I'm thankful someone asked the question. I was too :o to ask!

 

Second, thank you for the response above. It's very informative, although quite frankly I'm still trying to wrap my head around the concept of a Type 1.5! :)

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Thanks for all of the information. This is something I have been wondering about because of my age (24). Aside from being a little overweight (and that is only within the last couple of years), I have absolutely no risk factors for Type 2. My doctor is just thinking Type 2 at the moment. Iasked about C Peptide and GAD and she said they weren't necessary. She said C Peptide was unnecessary because we know I'm producing insulin since I go low. She said the GAD wouldn't tell us anything useful or change treatment. I thought about asking for an endo referral, but it doesn't seem like it will do any good at this point.

 

At what point did you realize that you did not have Type 2 but had Type 1.5?

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actually...i was wondering what the specific difference b/w MODY and LADA...MODY has many subcategories and is genetically markable..correct? What else...may need it's own thread though...

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EB, Type 2 was never really a consideration...i was briefly on insulin with gd and all over the place... i am definately not insulin resistant..which i think is part of GD (?) ...so it makes me wonder if the GD was assumed and that perhaps my BG was higher b/c of the extra demands on my body at the time vs true GD...I imagine it would have been very frustrating otherwise..my grnadmother was insulin dependent before she died, but i think her pancreas was shot due to other medications she was on vs.resistant...guess I'll never be sure. i did have 2 uncles (grandmother and grandfathers brothers) with type 1 who died very young...but that is it.

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Type 1.5 is referred to as "LADA" or "Latent Autoimmune Diabetes in Adults".

 

Diabetes Monitor describes LADA as follows:

[sNIP]

 

Thanks so very much.

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