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seacomp

Metformin - When to Take

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I joined this forum because I wanted to reply to a thread on Metformin (Glucophage). This a great drug to lower insulin resistance and liver derived glucose, if you can take it. I, personally can no longer take it, because of a drug interaction.

However, it must be taken correctly with meals. If it is taken on an empty stomach, only some of the drug is absorbed and you get only partial benefit.

This information is included in the circular that is distributed with Glucophage (the branded product), but (likely) not with the generic Metformin.

It is advised to take many drugs with food to reduce/eliminate potential upset stomach, etc. This is not the case with metformin: the efficency of the drugs demands it be taken with food.

Many pcp doctors do not know this so will not correctly advise you.

But it is the case. As one web site put it "the extent of metformin absorption (as measured by AUC) from the GLUCOPHAGE XR tablet increased by approximately 50% when given with food"

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Thanks for the information. I have always taken my Metformin right before I am ready to eat breakfast and dinner.

 

Karen

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I take 1 500mg. of Glucophage and 1mg of Amaryl after breakfast and 1 500mg. of Glucophage after dinner.

Last A1c was 5.8.:hello:

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Found out about this through trial and error :eating:

 

For me, it is most effective when I take the tablets after I have had 2 bites of my meal. I take the tablets then... I continue with my meal. I have stopped taking the tablets before my meal as I would always end up eating much later. You know, kids, etc.

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Thanks for the tip. I have been taking my Metformin anything from half an hour before a meal to about an hour afterwards! I shall now make sure it's always my 'first course' of a meal :biggrin:

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I always take my Metformin with meals (either during, before or straight after eating). I am on three tablets a day; so I have one with breakfast, one with lunch, and one with dinner. My Metformin comes with a label the pharmacy puts on stating "Take with food".

 

Thanks for this info though, as many obviously did not know about it :(

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This is definately true. I thoroughly read the inserts with my metformin and the pharmacist and I looked at the inserts for glucophage and they refer, as in the quote above, to the XR which is the extended release. We couldn't find whether or not it applied to the regular as well.

 

So I started taking it in the mornings without food. After a few weeks I went back to taking it with food. It definately works better when taken with food. No bout adoubt it!

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It's a shame that the leaflet that comes with Metformin (certainly in the UK) doesn't mention anything about the relationship between taking the drug with food and absorption rates. If it did then patients would be better informed and would probably be more strict about exactly when they take it, I know I would have. All my doc ever said about it was that the reason for taking Metformin 'around mealtimes' was to help reduce any gastric distress, nothing about it affecting the effectiveness of the drug.

 

Oh well, at least I know now :biggrin:

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