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Harley Dave


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Harley Dave

Was just reading about Welchol. Has anyone here had experience with this medicine? Dr put me on 500 mg Metformin and 10 mg Pravastatin. These meds do not seem like they are doing much. Been on them for about 5 weeks now.



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500mg Met is a very low dosage; I would be surprised if your doctor does not increase it. The statin is not going to have any effect on your BG ... it's to treat the high triglycerides and cholesterol levels (which are caused by high BGs)


Welchol (colesevelam) is not a statin, but is designed to reduce LDL levels through a different mechanism. It can be prescribed along with a statin or instead of it. Welchol is also claimed to "improve glycaemic control in T2 diabetes".


Note: Welchol will ***INCREASE*** Triglyceride levels, especially if used with insulin or sulpha drugs.


Primary action: it is a non-absorbed, lipid-lowering polymer that binds bile acids in the intestine, impeding their reabsorption. As the bile acid pool becomes depleted, the hepatic enzyme, cholesterol 7-α-hydroxylase, is upregulated, which increases the conversion of cholesterol to bile acids. This causes an increased demand for cholesterol in the liver cells, resulting in the dual effect of decreasing transcription and activity of the cholesterol biosynthetic enzyme, HMG-CoA reductase, and increasing the number of hepatic LDL receptors. These compensatory effects result in increased clearance of LDL-C from the blood, resulting in decreased serum LDL-C levels. Serum TG levels may increase or remain unchanged.


It is not yet known how Colesevelam works to help control blood sugar in people with type 2 diabetes. However, it is clear that the drug works within the digestive tract, since it is not absorbed into the rest of the body.



Note that by eating a diet rich in saturated fats, you are NATURALLY exhausting your stored bile acids ...

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